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Common and Preferred Stock - Additional Information (Detail) - USD ($)
$ / shares in Units, $ in Thousands
 1 Months Ended 3 Months Ended 12 Months Ended
Oct. 09, 2020
Jun. 24, 2020
Feb. 28, 2022
Feb. 28, 2021
Dec. 31, 2020
Jun. 30, 2020
Feb. 28, 2018
Dec. 31, 2020
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Oct. 31, 2021
Aug. 31, 2019
Class of Stock [Line Items]                          
Common stock, shares authorized                 400,000,000 400,000,000      
Common stock, par value                 $ 0.01 $ 0.01      
Undesignated preferred stock, shares authorized                 10,000,000 10,000,000      
Undesignated preferred stock, par value                 $ 0.01 $ 0.01      
Common stock, shares issued                 263,793,305 251,477,562      
Common stock, shares outstanding                 263,793,305 251,477,562      
Undesignated preferred stock, shares outstanding                 0 0      
Common stock, shares authorized                 $ 2,638 $ 2,515      
Proceeds from stock purchase plans                 $ 700 $ 100      
Market price stock purchase plan                 252,176 25,000      
MidCap Credit Facility                          
Class of Stock [Line Items]                          
Common stock, shares issued                       964,113  
Class of Warrant or Right, Number of Securities Called by Warrants or Rights                       1,283,467  
QrumPharma                          
Class of Stock [Line Items]                          
Number of common stock issued         3,067,179                
MidCap Credit Facility                          
Class of Stock [Line Items]                          
Warrants to purchase of common stock         111,853     111,853     111,853    
Underwriting Agreement                          
Class of Stock [Line Items]                          
Number of shares sold during the period           26,666,667              
Class of Warrant or Right, Number of Securities Called by Warrants or Rights           7,250,000              
Exercise price of warrants           $ 1.60              
Class of Warrant or Right, Outstanding           26,666,667              
Remaining Warrants Available for Purchase           0              
Convertible Promissory Note | The Mann Group L L C                          
Class of Stock [Line Items]                          
Issuance of common stock to note holders               2,800,000 4,000,000 4,000,000      
Conversion of notes accrued interest to common shares, value               $ 3,000   $ 400      
Conversion of notes accrued interest to common shares               1,200,000          
Debt issuance amount               $ 7,000 $ 10,000 9,600      
Common stock issued to pay interest                 75,487        
2024 Convertible Notes                          
Class of Stock [Line Items]                          
Issuance of common stock to note holders       1,666,667                  
Debt issuance amount       $ 5,000                  
Tranche 1 | MidCap Credit Facility                          
Class of Stock [Line Items]                          
Exercise price of warrants                         $ 1.11
Warrants to purchase of common stock                       1,171,614 1,171,614
Tranche 2 | MidCap Credit Facility                          
Class of Stock [Line Items]                          
Exercise price of warrants         $ 2.91     $ 2.91     $ 2.91    
Warrants to purchase of common stock         111,853     111,853     111,853 111,853  
Common Stock                          
Class of Stock [Line Items]                          
Number of shares sold during the period                 5,060,000        
Common Stock | June 2020 Note                          
Class of Stock [Line Items]                          
Issuance of common stock to note holders   1,235,094                      
Common Stock | December 2020 Note                          
Class of Stock [Line Items]                          
Issuance of common stock to note holders 1,377,356                        
Contolled Equity Offering Sales Agreement | Cantor Fitzgerald                          
Class of Stock [Line Items]                          
Stock purchase agreements date             Feb. 28, 2018            
Contolled Equity Offering Sales Agreement | Cantor Fitzgerald | Common Stock                          
Class of Stock [Line Items]                          
Common stock, shares authorized             $ 50,000            
Contolled Equity Offering Sales Agreement | Cantor Fitzgerald | Common Stock | Maximum                          
Class of Stock [Line Items]                          
Amount of net proceeds from issuance of securities     $ 50,000                    
At Market Issuance Sales Agreement | Cantor Fitzgerald | Common Stock                          
Class of Stock [Line Items]                          
Amount of net proceeds from issuance of securities                 $ 19,800 $ 1,900 $ 23,500    
Number of shares sold during the period                 5,059,856 578,063 11,851,566    
At Market Issuance Sales Agreement | Cantor Fitzgerald | Common Stock | Weighted Average                          
Class of Stock [Line Items]                          
Exchange price per share         $ 1.99     $ 1.99 $ 3.91 $ 3.26 $ 1.99