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Components of Net Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2023 | Dec. 31, 2022
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 506,641 | $ 542,537
Research and development credits | 77,007 | 78,804
Capitalized research costs | 14,225 | 4,369
Milestone Rights | 1,006 | 1,331
Accrued expenses | 3,760 | 2,675
Loss on purchase commitment | 22,806 | 23,117
Non-qualified stock option expense | 3,559 | 7,686
Capitalized patent costs | 6,720 | 8,058
Other | 3,405 | 3,204
Lease liability | 1,280 | 1,624
Interest expense limitation | 2,782 | 10,991
Depreciation | 21,134 | 22,157
Deferred product revenue and costs | 346 | 370
Sale of future royalties | 34,848 |
Total deferred tax assets | 699,519 | 706,923
Valuation allowance | (698,228) | (705,034)
Net deferred tax assets | 1,291 | 1,889
Deferred tax liabilities: |  |
Right of use asset | (1,121) | (1,640)
Other prepaids | (176) | (249)
Total deferred tax liabilities | (1,297) | $ (1,889)
Net deferred tax assets | $ (6) |

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