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Pay vs Performance Disclosure - USD ($) | 12 Months Ended
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Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Pay vs Performance Disclosure |  |  |  |  |
Pay vs Performance Disclosure, Table |
Year |  | Summary Compensation Table Total for PEO(1) |  | Compensation Actually Paid to PEO(1)(2)(3) |  | Average Summary Compensation Table Total for Non-PEO NEOs(1) |  | Average Compensation Actually Paid to Non-PEO NEOs(1)(2)(3) |  | Value of Initial Fixed $100 Investment based on:(4) |  | Net Loss(5) (in thousands) |  | Net Product Sales(6) (in thousands)
|  |  |  |  | Total Shareholder Return |  | Peer Group Total Shareholder Return |  |
2025 |  | $ | 8,457,151 |  |  | $ | 24,497,149 |  |  | $ | 2,452,691 |  |  | $ | 6,034,347 |  |  | $ | 140.19 |  |  | $ | 124.75 |  |  | $ | (25,546) |  |  | $ | 410,460 |
2024 |  | $ | 5,204,877 |  |  | $ | 10,947,263 |  |  | $ | 1,553,201 |  |  | $ | 2,746,215 |  |  | $ | 122.68 |  |  | $ | 118.20 |  |  | $ | (321,545) |  |  | $ | 226,707 |
2023 |  | $ | 7,574,959 |  |  | $ | 885,487 |  |  | $ | 2,011,803 |  |  | $ | 320,994 |  |  | $ | 63.31 |  |  | $ | 118.87 |  |  | $ | (111,399) |  |  | $ | 127,537 |
2022 |  | $ | 5,753,490 |  |  | $ | 687,242 |  |  | $ | 2,238,982 |  |  | $ | 1,118,268 |  |  | $ | 148.10 |  |  | $ | 113.65 |  |  | $ | (278,482) |  |  | $ | 200,528 |
2021 |  | $ | 5,739,010 |  |  | $ | 6,564,795 |  |  | $ | 2,138,273 |  |  | $ | 1,957,099 |  |  | $ | 218.59 |  |  | $ | 126.45 |  |  | $ | (180,091) |  |  | $ | 210,776 |
Company Selected Measure Name | net product sales |  |  |  |
Named Executive Officers, Footnote | Eric Dube was our PEO for each year presented. The individuals comprising the Non-PEO NEOs for each year presented are listed below. 2025: Christopher Cline, Peter Heerma, Jula Inrig and William E. Rote. 2024: Christopher Cline, Peter Heerma, Jula Inrig and William E. Rote. 2023: Christopher Cline, Peter Heerma, Elizabeth Reed and William E. Rote. 2022: Laura Clague, Christopher Cline, Peter Heerma, Jula Inrig and William E. Rote. 2021: Laura Clague, Elizabeth Reed, Noah Rosenberg and William E. Rote. |  |  |  |
Peer Group Issuers, Footnote | The Peer Group TSR set forth in this table utilizes the NASDAQ Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Report for the year ended December 31, 2025. The comparison assumed $100 was invested for the period starting December 31, 2019, through the end of the listed year in the Company and in the NASDAQ Biotechnology Index, respectively. Historical stock performance is not necessarily indicative of future stock performance. |  |  |  |
PEO Total Compensation Amount | $ 8,457,151 | $ 5,204,877 | $ 7,574,959 | $ 5,753,490 | $ 5,739,010
PEO Actually Paid Compensation Amount | $ 24,497,149 | 10,947,263 | 885,487 | 687,242 | 6,564,795
Adjustment To PEO Compensation, Footnote | Compensation Actually Paid is computed in accordance with Item 402(v) of Regulation S-K for the PEO and the Non-PEO NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Stock Awards and Options Awards column are the total from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table for the applicable year.
Year |  | NEO |  | Average Summary Compensation Table Total |  | Deduct: Average of Stock Awards and Option Awards |  | Add: Average Equity Adjustments |  | Average Compensation Actually Paid
2025 |  | PEO |  | $ | 8,457,151 |  |  | $ | 6,623,904 |  |  | $ | 22,663,902 |  |  | $ | 24,497,149 |
2025 |  | non-PEO |  | $ | 2,452,691 |  |  | $ | 1,498,484 |  |  | $ | 5,080,140 |  |  | $ | 6,034,347 |
The amounts in the Total Equity Adjustments columns in the tables above are derived from the amounts set forth in the following tables:
Year |  | NEO |  | Average Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year |  | Average Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards |  | Average Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year |  | Average Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year |  | Average Fair Value of Last Day of Prior Year of Equity Awards Forfeited During Year |  | Total Average Equity Adjustments*
2025 |  | PEO |  | $ | 12,142,762 |  |  | $ | 8,910,390 |  |  | $ | — |  |  | $ | 1,610,750 |  |  | $ | — |  |  | $ | 22,663,902 |
2025 |  | non-PEO |  | $ | 2,793,169 |  |  | $ | 1,827,374 |  |  | $ | — |  |  | $ | 459,597 |  |  | $ | — |  |  | $ | 5,080,140 |
* The valuation assumptions used to calculate fair values did not materially differ from those disclosed at the time of grant. |  |  |  |
Non-PEO NEO Average Total Compensation Amount | $ 2,452,691 | 1,553,201 | 2,011,803 | 2,238,982 | 2,138,273
Non-PEO NEO Average Compensation Actually Paid Amount | $ 6,034,347 | 2,746,215 | 320,994 | 1,118,268 | 1,957,099
Adjustment to Non-PEO NEO Compensation Footnote | Compensation Actually Paid is computed in accordance with Item 402(v) of Regulation S-K for the PEO and the Non-PEO NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Stock Awards and Options Awards column are the total from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table for the applicable year.
Year |  | NEO |  | Average Summary Compensation Table Total |  | Deduct: Average of Stock Awards and Option Awards |  | Add: Average Equity Adjustments |  | Average Compensation Actually Paid
2025 |  | PEO |  | $ | 8,457,151 |  |  | $ | 6,623,904 |  |  | $ | 22,663,902 |  |  | $ | 24,497,149 |
2025 |  | non-PEO |  | $ | 2,452,691 |  |  | $ | 1,498,484 |  |  | $ | 5,080,140 |  |  | $ | 6,034,347 |
The amounts in the Total Equity Adjustments columns in the tables above are derived from the amounts set forth in the following tables:
Year |  | NEO |  | Average Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year |  | Average Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards |  | Average Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year |  | Average Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year |  | Average Fair Value of Last Day of Prior Year of Equity Awards Forfeited During Year |  | Total Average Equity Adjustments*
2025 |  | PEO |  | $ | 12,142,762 |  |  | $ | 8,910,390 |  |  | $ | — |  |  | $ | 1,610,750 |  |  | $ | — |  |  | $ | 22,663,902 |
2025 |  | non-PEO |  | $ | 2,793,169 |  |  | $ | 1,827,374 |  |  | $ | — |  |  | $ | 459,597 |  |  | $ | — |  |  | $ | 5,080,140 |
* The valuation assumptions used to calculate fair values did not materially differ from those disclosed at the time of grant. |  |  |  |
Compensation Actually Paid vs. Total Shareholder Return | Description of Relationship Between PEO and Non-PEO NEO Compensation Actually Paid and Company Total Shareholder Return ("TSR") The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our Non-PEO NEOs, and the Company's cumulative TSR over the five most recently completed fiscal years. |  |  |  |
Compensation Actually Paid vs. Net Income | Description of Relationship Between PEO and Non-PEO NEO Compensation Actually Paid and Net Income The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our Non-PEO NEOs, and our net income during the five most recently completed fiscal years. The net product sales shown for years prior to 2023 include revenue from products in the Company’s bile acid portfolio which was divested in August 2023. The Company’s 2023, 2024 and 2025 net product sales do not include any revenue from the bile acid portfolio, which was classified as discontinued operations in 2023. |  |  |  |
Compensation Actually Paid vs. Company Selected Measure | Description of Relationship Between PEO and Other NEO Compensation Actually Paid and Net Product Sales The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our Non-PEO NEOs, and our net product sales during the five most recently completed fiscal years. |  |  |  |
Total Shareholder Return Vs Peer Group | Description of Relationship Between PEO and Non-PEO NEO Compensation Actually Paid and Company Total Shareholder Return ("TSR") The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our Non-PEO NEOs, and the Company's cumulative TSR over the five most recently completed fiscal years. |  |  |  |
Total Shareholder Return Amount | $ 140.19 | 122.68 | 63.31 | 148.10 | 218.59
Peer Group Total Shareholder Return Amount | 124.75 | 118.20 | 118.87 | 113.65 | 126.45
Net Income (Loss) | $ (25,546,000) | $ (321,545,000) | $ (111,399,000) | $ (278,482,000) | $ (180,091,000)
Company Selected Measure Amount | 410,460,000 | 226,707,000 | 127,537,000 | 200,528,000 | 210,776,000
PEO Name | (1)Eric Dube |  |  |  |
Additional 402(v) Disclosure | Pay Versus Performance In accordance with rules adopted by the Securities and Exchange Commission pursuant to the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2020, we provide the following disclosure regarding executive compensation for our principal executive officer ("PEO") and Non-PEO NEOs and Company performance for the fiscal years listed below. The Compensation Committee did not consider the pay versus performance disclosure below in making its pay decisions for any of the years shown. Required Tabular Disclosure of Pay Versus Performance The amounts set forth below under the headings “Compensation Actually Paid to PEO” and “Average Compensation Actually Paid to non-PEO NEOs” have been calculated in a manner consistent with Item 402(v) of Regulation S-K. Use of the term “compensation actually paid” is required by the SEC’s rules and as a result of the calculation methodology required by the SEC, such amounts differ from compensation actually received by the individuals and the compensation decisions described in the “Compensation Discussion and Analysis” section above. The amounts shown for Compensation Actually Paid have been calculated in accordance with Item 402(v) of Regulation S-K and do not reflect compensation actually earned, realized, or received by the Company's NEOs. These amounts reflect the Summary Compensation Table total with certain adjustments as described in footnote 3 below.The dollar amounts reported represent the amount of net loss reflected in the Company's audited financial statements for the applicable fiscal year. Required Tabular List of Most Important Financial Performance Measures As is the case with many companies of a similar stage in the biotechnology industry, the Company relies less on financial performance goals as compared to non-financial strategic and operational goals with respect to setting compensation for the NEOs. For the fiscal year ended December 31, 2025, aside from net product sales, which is the company-selected financial measure, the Company did not use other financial performance measures to link Compensation Actually Paid to our NEOs to company performance. For a discussion of the non-financial strategic and operational goals the Company factors into the compensation program for the NEOs, please see the “Compensation Discussion and Analysis” section above. All of the information provided above under the "Item 402(v) Pay Versus Performance” heading will not be deemed to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, whether made before or after the date hereof and irrespective of any general incorporation language in any such filing, except to the extent the Company specifically incorporates such information by reference. |  |  |  |
Measure:: 1 |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Non-GAAP Measure Description | We determined net product sales to be the most important financial performance measure used to link Company performance to Compensation Actually Paid to our PEO and Non-PEO NEOs in 2025. The net product sales reported in the table for each fiscal year are from the respective Form 10-K filed for that year. This performance measure may not have been the most important financial performance measure for certain past years and we may determine a different financial performance measure to be the most important financial performance measure in future years. The net product sales shown for years prior to 2023 include revenue from products in the Company’s bile acid product portfolio including Cholbam (cholic acid) and Chenodal (chenodal) ("the bile acid portfolio"), which was sold to Mirum Pharmaceuticals in August 2023. The Company’s 2023, 2024 and 2025 net product sales do not include any revenue from the bile acid portfolio, which was classified as discontinued operations in 2023. |  |  |  |
PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | $ (6,623,904) |  |  |  |
PEO | Equity Awards Adjustments, Excluding Value Reported in Compensation Table |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 22,663,902 |  |  |  |
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 12,142,762 |  |  |  |
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 8,910,390 |  |  |  |
PEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 0 |  |  |  |
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 1,610,750 |  |  |  |
PEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 0 |  |  |  |
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | (1,498,484) |  |  |  |
Non-PEO NEO | Equity Awards Adjustments, Excluding Value Reported in Compensation Table |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 5,080,140 |  |  |  |
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 2,793,169 |  |  |  |
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 1,827,374 |  |  |  |
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 0 |  |  |  |
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 459,597 |  |  |  |
Non-PEO NEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | $ 0 |  |  |  |

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