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Note 7 - Share-based Compensation - Summary of Stock Option Activity (Details) - Employee and Nonemployee Stock Option [Member] - USD ($)
$ / shares in Units, $ in Thousands
 6 Months Ended
Jun. 30, 2022
Outstanding, shares under options (in shares) 98,671
Outstanding, weighted average exercise price (in dollars per share) $ 33.53
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross (in shares) 9,876
Granted (in dollars per share) $ 77.28
Exercised, shares under options (in shares) (1,295)
Granted, weighted average exercise price (in dollars per share) $ 16.32
Outstanding, shares under options (in shares) 107,252
Outstanding, weighted average exercise price (in dollars per share) $ 37.77
Outstanding, weighted average remaining contractual life (Year) 5 years 9 months 21 days
Outstanding, aggregate intrinsic value $ 4,483
Exercisable, shares under options (in shares) 97,376
Exercisable, weighted average exercise price (in dollars per share) $ 33.76
Exercisable, weighted average remaining contractual life (Year) 5 years 4 months 20 days
Exercisable, aggregate intrinsic value $ 4,461
Vested and expected to vest, shares under options (in shares) 107,252
Vested and expected to vest, weighted average exercise price (in dollars per share) $ 37.77
Vested and expected to vest, weighted average remaining contractual life (Year) 5 years 9 months 21 days
Vested and expected to vest, aggregate intrinsic value $ 4,483