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Note 7 - Share-based Compensation - Summary of Stock Option Activity (Details) - Employee and Nonemployee Stock Option [Member]
$ / shares in Units, $ in Thousands
 3 Months Ended
Mar. 31, 2023
USD ($)
$ / shares
shares
Outstanding, shares under options (in shares) | shares 92,075
Outstanding, weighted average exercise price (in dollars per share) | $ / shares $ 39.98
Granted, shares under options (in shares) | shares 7,935
Granted (in dollars per share) | $ / shares $ 111.54
Exercised, shares under options (in shares) | shares (3,780)
Granted, weighted average exercise price (in dollars per share) | $ / shares $ 28.94
Outstanding, shares under options (in shares) | shares 96,230
Outstanding, weighted average exercise price (in dollars per share) | $ / shares $ 46.31
Outstanding, weighted average remaining contractual life (Year) 5 years 8 months 4 days
Outstanding, aggregate intrinsic value | $ $ 8,038
Exercisable, shares under options (in shares) | shares 78,419
Exercisable, weighted average exercise price (in dollars per share) | $ / shares $ 35.81
Exercisable, weighted average remaining contractual life (Year) 5 years 3 months 21 days
Exercisable, aggregate intrinsic value | $ $ 7,374
Vested and expected to vest, shares under options (in shares) | shares 96,230
Vested and expected to vest, weighted average exercise price (in dollars per share) | $ / shares $ 46.31
Vested and expected to vest, weighted average remaining contractual life (Year) 5 years 8 months 4 days
Vested and expected to vest, aggregate intrinsic value | $ $ 8,038