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Commitment and Contingencies - Additional Information (Details) - USD ($) | 12 Months Ended | 31 Months Ended |
--- | --- | --- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Feb. 28, 2019 | Jan. 10, 2022
Commitments And Contingencies [Line Items] |  |  |  |
Operating lease, description | The Company entered into an office space lease at 121 First Street in Cambridge, Massachusetts on January 10, 2022, for 36 months, with an option to extend the lease for 3 years. |  |  |
Operating lease, term of contract |  |  |  | 36 months
Operating lease, renewal term |  |  |  | 3 years
Restricted cash equivalents | $ 719,000 | $ 189,000 |  |
Funding received from grantors | 0 | $ 300,000 |  |
ALS Association and ALS Finding a Cure | Cost of Sales |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |
Royalty expense | 1,400,000 |  |  |
Royalty Payments Agreements with Grantors |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |
Funding received from grantors |  |  | $ 4,300,000 |
Royalty Payments Agreements with Grantors | ALS Association and ALS Finding a Cure |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |
Percentage of grant received |  |  | 150.00% |
Percentage of net sales of products developed under projects |  |  | 3.00% |
Percentage of cash proceeds from revenue generating transaction |  |  | 3.00% |
Royalty Payments Agreements with Grantors | Alzheimer's Drug Discovery Foundation, the Alzheimer's Association, and Cure Alzheimer's Fund |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |
Maximum Royalty amount payable to each grantor |  |  | $ 15,000,000.0 |
Aggregate royalty amount payable to grantor |  |  | $ 45,000,000.0 |
Percentage of annual net sales of products commercialized from project |  |  | 4.00% |
Percentage of all royalties and cash proceeds from revenue generating transaction |  |  | 15.00% |
Collateral for Letter of Credit Issued |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |
Restricted cash | 200,000 |  |  |
Collateral for Corporate Credit Card Program |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |
Restricted cash | $ 500,000 |  |  |

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