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Commitment and Contingencies - Additional Information (Details) - USD ($)	12 Months Ended		31 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Feb. 28, 2019	Jan. 10, 2022
Commitments And Contingencies [Line Items]
Operating lease, description	The Company entered into an office space lease at 121 First Street in Cambridge, Massachusetts on January 10, 2022, for 36 months, with an option to extend the lease for 3 years.
Operating lease, term of contract				36 months
Operating lease, renewal term				3 years
Restricted cash equivalents	$ 719,000	$ 189,000
Funding received from grantors	0	$ 300,000
ALS Association and ALS Finding a Cure | Cost of Sales
Commitments And Contingencies [Line Items]
Royalty expense	1,400,000
Royalty Payments Agreements with Grantors
Commitments And Contingencies [Line Items]
Funding received from grantors			$ 4,300,000
Royalty Payments Agreements with Grantors | ALS Association and ALS Finding a Cure
Commitments And Contingencies [Line Items]
Percentage of grant received			150.00%
Percentage of net sales of products developed under projects			3.00%
Percentage of cash proceeds from revenue generating transaction			3.00%
Royalty Payments Agreements with Grantors | Alzheimer's Drug Discovery Foundation, the Alzheimer's Association, and Cure Alzheimer's Fund
Commitments And Contingencies [Line Items]
Maximum Royalty amount payable to each grantor			$ 15,000,000.0
Aggregate royalty amount payable to grantor			$ 45,000,000.0
Percentage of annual net sales of products commercialized from project			4.00%
Percentage of all royalties and cash proceeds from revenue generating transaction			15.00%
Collateral for Letter of Credit Issued
Commitments And Contingencies [Line Items]
Restricted cash	200,000
Collateral for Corporate Credit Card Program
Commitments And Contingencies [Line Items]
Restricted cash	$ 500,000

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