    <SEC-DOCUMENT>0000950170-23-015281-index.html : 20230427
    <SEC-HEADER>0000950170-23-015281.hdr.sgml : 20230427
    <ACCEPTANCE-DATETIME>20230427161351
    ACCESSION NUMBER:		0000950170-23-015281
    CONFORMED SUBMISSION TYPE:	DEFA14A
    PUBLIC DOCUMENT COUNT:		3
    FILED AS OF DATE:		20230427
    DATE AS OF CHANGE:		20230427

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Amylyx Pharmaceuticals, Inc.
    		CENTRAL INDEX KEY:			0001658551
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				464600503
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEFA14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-41199
    		FILM NUMBER:		23857036

    	BUSINESS ADDRESS:
    		STREET 1:		43 THORNDIKE STREET
    		CITY:			CAMBRIDGE
    		STATE:			MA
    		ZIP:			02141
    		BUSINESS PHONE:		617-683-0917

    	MAIL ADDRESS:
    		STREET 1:		43 THORNDIKE STREET
    		CITY:			CAMBRIDGE
    		STATE:			MA
    		ZIP:			02141
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEFA14A
    <SEQUENCE>1
    <FILENAME>amlx-defa14a-2023-additi.htm
    <DESCRIPTION>DEFA14A
    <TEXT>
    Document 1 - file: amlx-defa14a-2023-additi.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>img43653419_0.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: img43653419_0.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>img43653419_1.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: img43653419_1.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>