<SEC-DOCUMENT>0001950047-24-003736.txt : 20240515
<SEC-HEADER>0001950047-24-003736.hdr.sgml : 20240515
<ACCEPTANCE-DATETIME>20240515163110
ACCESSION NUMBER:		0001950047-24-003736
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20240515
DATE AS OF CHANGE:		20240515

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Amylyx Pharmaceuticals, Inc.
		CENTRAL INDEX KEY:			0001658551
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				464600503
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-41199
		FILM NUMBER:		24951537

	BUSINESS ADDRESS:	
		STREET 1:		43 THORNDIKE STREET
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02141
		BUSINESS PHONE:		617-683-0917

	MAIL ADDRESS:	
		STREET 1:		43 THORNDIKE STREET
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02141

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Mazzariello Gina
		CENTRAL INDEX KEY:			0001913765
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		C/O AMYLYX PHARMACEUTICALS, INC.
		STREET 2:		43 THORNDIKE STREET
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02141
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001913765</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
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            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
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    <formData>
        <issuerInfo>
            <issuerCik>0001658551</issuerCik>
            <issuerName>Amylyx Pharmaceuticals, Inc.</issuerName>
            <secFileNumber>001-41199</secFileNumber>
            <issuerAddress>
                <ns2:street1>43 THORNDIKE STREET</ns2:street1>
                <ns2:city> CAMBRIDGE</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02141</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>617-683-0917</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>GINA MAZZARIELLO</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>COMMON</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>10455</noOfUnitsSold>
            <aggregateMarketValue>19550.85</aggregateMarketValue>
            <noOfUnitsOutstanding>68005749</noOfUnitsOutstanding>
            <approxSaleDate>05/15/2024</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>02/22/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>10455</amountOfSecuritiesAcquired>
            <paymentDate>02/22/2024</paymentDate>
            <natureOfPayment>N/A</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <remarks>The securities to be sold were acquired upon the vesting of restricted stock units during the period of 2/22/2024 through 3/1/2024
</remarks>
        <noticeSignature>
            <noticeDate>05/15/2024</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>12/14/2023</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Gina Mazzariello</signature>
        </noticeSignature>
    </formData>
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</SEC-DOCUMENT>
