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Segments | 3 Months Ended
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Mar. 31, 2026
Segment Reporting [Abstract] |
Segments | 11. Segments The Company views its operations and manages its business as one operating segment and reporting unit. Our operating segments are determined based on how our Co-Chief Executive Officers, who collectively serve as our chief operating decision makers, or CODM, manage our business, regularly access discrete financial information, and evaluate performance for operating decision-making purposes, including allocation of resources or capital to specific compounds or projects in line with the Company’s overall strategies and goals. The Company’s entire business is managed by a single management team, which reports to the CODM. The CODM assess segment performance and decide how to allocate resources based on consolidated net loss. The CODM use net loss to monitor budget and forecast versus actual results in assessing segment performance and to determine how to allocate resources. The measure of segment assets used in determining how to manage and allocate resources is reported on the consolidated balance sheets as total assets. A ll of the Company's long-lived assets were held within the U.S. The following table reconciles segment revenue and expenses to consolidated net loss for the three months ended March 31, 2026 and 2025 (in thousands):
|  | Three Months Ended March 31, |
|  | 2026 |  |  | 2025 |
Direct research and development expenses by program 1,2: |  |  |  |  |  |
Avexitide |  | $ | 9,990 |  |  | $ | 5,426 |
AMX0035 - PSP |  |  | 649 |  |  |  | 4,563 |
Other programs 3 |  |  | 7,977 |  |  |  | 3,772 |
Personnel-related research and development 4 |  |  | 8,994 |  |  |  | 8,358 |
Selling, general and administrative |  |  | 16,169 |  |  |  | 15,684 |
Interest income |  |  | (2,570 | ) |  |  | (2,231 | )
Other segment items 5 |  |  | 75 |  |  |  | 335 |
Net loss |  | $ | (41,284 | ) |  | $ | (35,907 | )
1. The significant expense categories and amounts align with the segment-level information that is regularly provided to the CODM. As the Company has one reportable segment, there were no intersegment eliminations for the three months ended March 31, 2026 and 2025. 2. Depreciation and amortization expense of $0.1 million during the three months ended March 31, 2026, and $0.2 million during the three months ended March 31, 2025, are allocated across the significant expense captions. 3. Other programs includes milestone payments totaling $4.0 million made to Gubra following the selection and handover of AMX0318 as a development candidate for PBH and other rare diseases during the three months ended March 31, 2026. 4. The Company does not allocate personnel and other similar costs to specific programs because these costs are deployed across multiple programs. 5. Other segment items primarily consists of net realized and unrealized losses on foreign exchange transactions.

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- Definition The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 21 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-21 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name 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