<SEC-DOCUMENT>0001193125-26-004404.txt : 20260106
<SEC-HEADER>0001193125-26-004404.hdr.sgml : 20260106
<ACCEPTANCE-DATETIME>20260106160503
ACCESSION NUMBER:		0001193125-26-004404
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20260106
DATE AS OF CHANGE:		20260106

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Amylyx Pharmaceuticals, Inc.
		CENTRAL INDEX KEY:			0001658551
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				464600503
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-41199
		FILM NUMBER:		26511392

	BUSINESS ADDRESS:	
		STREET 1:		55 CAMBRIDGE PARKWAY
		STREET 2:		SUITE 6W
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142
		BUSINESS PHONE:		617-682-0917

	MAIL ADDRESS:	
		STREET 1:		55 CAMBRIDGE PARKWAY
		STREET 2:		SUITE 6W
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Klee Justin B.
		CENTRAL INDEX KEY:			0001898314
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		C/O AMYLYX PHARMACEUTICALS, INC.
		STREET 2:		43 THORNDIKE STREET
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02141
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<headerData>
<submissionType>144</submissionType>
<filerInfo>
<filer>
<filerCredentials>
<cik>0001898314</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>
</filerInfo>
</headerData>
<formData>
<issuerInfo>
<issuerCik>0001658551</issuerCik>
<issuerName>Amylyx Pharmaceuticals, Inc.</issuerName>
<secFileNumber>001-41199</secFileNumber>
<issuerAddress>
<street1 xmlns="http://www.sec.gov/edgar/common">55 Cambridge Parkway</street1>
<street2 xmlns="http://www.sec.gov/edgar/common">Suite 6W</street2>
<city xmlns="http://www.sec.gov/edgar/common">Cambridge</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">02142</zipCode>
</issuerAddress>
<issuerContactPhone>617-682-0917</issuerContactPhone>
<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Klee Justin B.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
<relationshipsToIssuer>
<relationshipToIssuer>Officer</relationshipToIssuer>
<relationshipToIssuer>Director</relationshipToIssuer>
</relationshipsToIssuer>
</issuerInfo>
<securitiesInformation>
<securitiesClassTitle>Common</securitiesClassTitle>
<brokerOrMarketmakerDetails>
<name>Morgan Stanley Smith Barney LLC</name>
<address>
<street1 xmlns="http://www.sec.gov/edgar/common">1 New York Plaza</street1>
<street2 xmlns="http://www.sec.gov/edgar/common">8th Floor</street2>
<city xmlns="http://www.sec.gov/edgar/common">New York</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">10004</zipCode>
</address>
</brokerOrMarketmakerDetails>
<noOfUnitsSold>7715</noOfUnitsSold>
<aggregateMarketValue>85590</aggregateMarketValue>
<noOfUnitsOutstanding>3317586</noOfUnitsOutstanding>
<approxSaleDate>01/06/2026</approxSaleDate>
<securitiesExchangeName>NASDAQ</securitiesExchangeName>
</securitiesInformation>
<securitiesToBeSold>
<securitiesClassTitle>Common</securitiesClassTitle>
<acquiredDate>01/06/2026</acquiredDate>
<natureOfAcquisitionTransaction>Vesting of Restricted Stock Units</natureOfAcquisitionTransaction>
<nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
<isGiftTransaction>N</isGiftTransaction>
<amountOfSecuritiesAcquired>18750</amountOfSecuritiesAcquired>
<paymentDate>01/06/2026</paymentDate>
<natureOfPayment>N/A</natureOfPayment>
</securitiesToBeSold>
<nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
<remarks>This sale represents shares sold solely to satisfy tax withholding obligations arising from the vesting of restricted stock units.</remarks>
<noticeSignature>
<noticeDate>01/06/2026</noticeDate>
<signature>/s/ Joshua B. Cohen, as Attorney in Fact</signature>
</noticeSignature>
</formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
