<SEC-DOCUMENT>0001950047-26-000449.txt : 20260115
<SEC-HEADER>0001950047-26-000449.hdr.sgml : 20260115
<ACCEPTANCE-DATETIME>20260115161414
ACCESSION NUMBER:		0001950047-26-000449
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20260115
DATE AS OF CHANGE:		20260115

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Amylyx Pharmaceuticals, Inc.
		CENTRAL INDEX KEY:			0001658551
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				464600503
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-41199
		FILM NUMBER:		26536419

	BUSINESS ADDRESS:	
		STREET 1:		55 CAMBRIDGE PARKWAY
		STREET 2:		SUITE 6W
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142
		BUSINESS PHONE:		617-682-0917

	MAIL ADDRESS:	
		STREET 1:		55 CAMBRIDGE PARKWAY
		STREET 2:		SUITE 6W
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Klee Justin B.
		CENTRAL INDEX KEY:			0001898314
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		C/O AMYLYX PHARMACEUTICALS, INC.
		STREET 2:		43 THORNDIKE STREET
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02141
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001898314</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001658551</issuerCik>
            <issuerName>AMYLYX PHARMACEUTICALS INC</issuerName>
            <secFileNumber>001-41199</secFileNumber>
            <issuerAddress>
                <ns2:street1>43 THORNDIKE STREET</ns2:street1>
                <ns2:city> CAMBRIDGE</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02141</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>6176820917</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>JUSTIN KLEE</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>136193</noOfUnitsSold>
            <aggregateMarketValue>1916235.51</aggregateMarketValue>
            <noOfUnitsOutstanding>109819569</noOfUnitsOutstanding>
            <approxSaleDate>01/15/2026</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>01/15/2026</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>136193</amountOfSecuritiesAcquired>
            <paymentDate>01/15/2026</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>JUSTIN KLEE</name>
                <address>
                    <ns2:street1>43 THORNDIKE STREET</ns2:street1>
                    <ns2:city> CAMBRIDGE</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02141</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>01/06/2026</saleDate>
            <amountOfSecuritiesSold>7715</amountOfSecuritiesSold>
            <grossProceeds>85589.44</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>The sale of shares covered by this Form 144 were made pursuant to a pre-set sales plan adopted by the seller on 11/12/2025. The seller signed this Form 144 on 11/12/2025 pursuant to such pre-set sales plan and made the below representation as of such plan adoption date.</remarks>
        <noticeSignature>
            <noticeDate>01/15/2026</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Justin Klee</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
