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Note 1 - Significant Accounting Policies (Tables)
 6 Months Ended
Jun. 30, 2015
Notes Tables  
Available-for-sale Securities [Table Text Block]
    June 30, 2015
    Amortized
Cost		   Accrued
Interest		   Gross
Unrealized
Gains		   Gross
Unrealized
Losses		   Estimated
Fair Value
Obligations of U.S. Government and its agencies   $ 9,649     $ 16     $ 2     $ (6 )   $ 9,661  
Corporate debt securities     28,830       197       14       (34 )     29,007  
Certificates of deposit     15,030       13       3       (71 )     14,975  
                                         
Total investments   $ 53,509     $ 226     $ 19     $ (111 )   $ 53,643  
     
    December 31, 2014
    Amortized
Cost		   Accrued
Interest		   Gross
Unrealized
Gains		   Gross
Unrealized
Losses		   Estimated
Fair Value
Obligations of U.S. Government and its agencies   $ 20,307     $ 22     $ —     $ (23 )   $ 20,306  
Corporate debt securities     27,152       151       5       (47 )     27,261  
Certificates of deposit     11,838       6       —       (63 )     11,781  
                                         
Total investments   $ 59,297     $ 179     $ 5     $ (133 )   $ 59,348  
Available For Sale Securities Debt Maturities Fair Value [Table Text Block]
    2015   2014
Maturing in one year or less   $ 17,584     $ 18,232  
Maturing after one year through two years     23,012       25,459  
Maturing after two years     13,047       15,657  
                 
Total investments   $ 53,643     $ 59,348  
Schedule of Receivables from Collaborations [Table Text Block]
    June 30, 2015
    Billed   Unbilled   Total
U.S. Department of Health and Human Services   $ 2,258     $ 2,011     $ 4,269  
Shionogi & Co. Ltd.     27       —       27  
Total receivables   $ 2,285     $ 2,011     $ 4,296  
    December 31, 2014
    Billed   Unbilled   Total
U.S. Department of Health and Human Services   $ —     $ 2,778     $ 2,778  
Shionogi & Co. Ltd.     1,071       —       1,071  
                         
Total receivables   $ 1,071     $ 2,778     $ 3,849  
Schedule of Inventory, Current [Table Text Block]
    2015   2014
Work in process   $ —     $ 267  
Finished Goods     1,308       416  
                 
Net inventories   $ 1,308     $ 683  
Schedule of Revenues from Collaborations [Table Text Block]
    Three Months   Six Months
    2015   2014   2015   2014
Product sales, net   $ —     $ —     $ 537     $ —  
Royalty revenue     132       125       1,650       1,946  
Collaborative and other research and development revenues:                                
U.S. Department of Health and Human Services     3,731       1,045       8,206       2,386  
Shionogi (Japan)     296       296       592       592  
CSL Limited     21,683       —       21,683       —  
Total collaborative and other research and development revenues     25,710       1,341       30,481       2,978  
                                 
Total revenues   $ 25,842     $ 1,466     $ 32,668     $ 4,924  
Schedule of Weighted Average Number of Shares [Table Text Block]
    Three Months Ended
June 30,		   Six Months Ended
June 30,
    2015   2014   2015   2014
Weighted average shares outstanding, basic     72,642       63,647       72,492       61,629  
Weighted average dilutive stock options and restricted stock units     4,118       -       -       -  
                                 
Weighted average shares outstanding, diluted     76,760       63,647       72,492       61,629