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Note 1 - Significant Accounting Policies (Details Textual) - USD ($)
$ / shares in Units, shares in Thousands
 1 Months Ended 3 Months Ended 6 Months Ended
Mar. 03, 2015
Nov. 06, 2013
Jun. 30, 2015
Jun. 30, 2015
Jun. 30, 2014
Jun. 30, 2015
Jun. 30, 2014
Dec. 31, 2014
Mar. 09, 2011
Currency Hedge Agreement [Member]                  
Collateral Already Posted, Aggregate Fair Value     $ 0 $ 0   $ 0   $ 0  
Foreign Exchange Contract [Member] | Not Designated as Hedging Instrument [Member]                  
Derivative, Loss on Derivative           (332,000) $ (3,350,000)    
Derivative, Gain on Derivative           1,545,000      
JPR Royalty Sub LLC [Member]                  
Revenue Recognition Royalty and Milestone Revenue Recognized                 $ 30,000,000
Certificates of Deposit [Member]                  
Restricted Cash and Cash Equivalents, Current     150,000 150,000   150,000      
Royalty Receivable [Member]                  
Restricted Cash and Cash Equivalents, Current     18,000 18,000   18,000      
Collateral for Credit [Member]                  
Restricted Cash and Cash Equivalents     1,401,000 1,401,000   $ 1,401,000      
Maximum [Member]                  
Maturity Period of High Quality Marketable Securities           3 years      
Average Maturity Period of High Quality Marketable Securities           1 year 180 days      
Maturity Period of Short Term Investment           1 year      
Average Maturity for Portfolio Investments           1 year 180 days      
Minimum [Member]                  
Maturity Period of Short Term Investment           90 days      
Long-term Investment Maturity, Minimum           1 year      
Agreement [Member] | RAPIVABMember | CSL [Member] | Contingent upon EU Marketing Approval [Member]                  
Proceeds from License Fees Received     7,000,000            
Agreement [Member] | RAPIVABMember | CSL [Member] | Revenue from Sale of Inventory to be Recognized When the Inventory Transfer Is Complete [Member]                  
Deferred Revenue, Additions     3,740,000            
Agreement [Member] | RAPIVABMember | CSL [Member] | Regulatory Support Revenue for Canadian and EU Marketing Approvals, Portion Recognized Ratably Over Expected Period of Involvement [Member]                  
Deferred Revenue, Additions     1,223,000            
Agreement [Member] | RAPIVABMember | CSL [Member]                  
Proceeds from License Fees Received     33,740,000            
Revenues     21,777,000            
Milestone Payment Maximum     12,000,000            
RAPIVABMember | Sales Revenue, Product Line [Member] | Customer Concentration Risk [Member]                  
Concentration Risk, Percentage           90.00%      
Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax           $ 12,000 0    
Amortization of Financing Costs       110,000 $ 110,000 220,000 220,000    
Loss on Sale of Investments           0      
Investments and Cash     131,993,000 131,993,000   131,993,000      
Securities Offered $ 150,000,000 $ 10,000,000              
Restricted Cash and Cash Equivalents, Current     $ 1,569,000 1,569,000   1,569,000   $ 150,000  
Revenues       25,842,000 1,466,000 32,668,000 4,924,000    
Interest Expense       $ 1,306,000 $ 1,225,000 $ 2,621,000 $ 2,467,000    
Earnings Per Share, Diluted       $ 0.06 $ (0.23) $ (0.14) $ (0.40)    
Earnings Per Share, Basic       $ 0.07 $ (0.23) $ (0.14) $ (0.40)    
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount         3,688 4,038 3,849