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Note 1 - Summary of Revenues (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2015	Jun. 30, 2014	Jun. 30, 2015	Jun. 30, 2014
US Department of Health and Human Services [Member]
Collaborative and other research and development revenues:
Collaborative and other research and development revenues	$ 3,731	$ 1,045	$ 8,206	$ 2,386
Shionogi and Co. Ltd [Member]
Collaborative and other research and development revenues:
Collaborative and other research and development revenues	296	$ 296	592	$ 592
CSL [Member]
Collaborative and other research and development revenues:
Collaborative and other research and development revenues	$ 21,683		21,683
Product sales, net			537
Royalty revenue	$ 132	$ 125	1,650	$ 1,946
Collaborative and other research and development revenues	25,710	1,341	30,481	2,978
Revenues	$ 25,842	$ 1,466	$ 32,668	$ 4,924

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- Definition

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+ References

No definition available.

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+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 225



-SubTopic 10



-Section S99



-Paragraph 2



-Subparagraph (SX 210.5-03.1)



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+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 225



-SubTopic 10



-Section S99



-Paragraph 2



-Subparagraph (SX 210.5-03.1(e))



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+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 225



-SubTopic 10



-Section S99



-Paragraph 2



-Subparagraph (SX 210.5-03.1(a))



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