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Note 2 - Stock-Based Compensation (Details Textual)
$ / shares in Units, shares in Thousands
1 Months Ended 6 Months Ended 12 Months Ended 15 Months Ended
Aug. 31, 2013
shares
Jun. 30, 2015
USD ($)
$ / shares
shares
Jun. 30, 2014
USD ($)
$ / shares
Dec. 31, 2014
shares
Jun. 30, 2015
USD ($)
shares
Unvested Performance Shares [Member] | Incentive Plan [Member]          
Allocated Share-based Compensation Expense   $ 0      
Stock Options and Restricted Stock [Member] | Incentive Plan [Member] | Vest 50% Each Year Until Fully Vested [Member]          
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage   50.00%      
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period   2 years      
Stock Options and Restricted Stock [Member]          
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized   $ 15,169,000     $ 15,169,000
Employee Service Share-based Compensation Nonvested Awards Compensation Cost Expected to be Recognized For Remainder of Fiscal Year   3,164,000      
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Two   5,192,000      
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Three   4,396,000      
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Four   2,277,000      
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Five   $ 140,000      
Performance Shares [Member] | Incentive Plan [Member] | Vest Upon Successful Completion of Specific Development Milestones [Member] | August 2013 [Member]          
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage         75.00%
Number of Milestones Achieved         3
Share-based Compensation Arrangement by Shar-based Payment Award, Awards Unvested, Percentage   25.00%      
Performance Shares [Member] | Incentive Plan [Member] | Vest Upon Successful Completion of Specific Development Milestones [Member] | December 2014 [Member]          
Share-based Compensation Arrangement by Shar-based Payment Award, Awards Unvested, Percentage   100.00%      
Performance Shares [Member] | Incentive Plan [Member] | Vest Upon Successful Completion of Specific Development Milestones [Member]          
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross | shares 1,032     1,250  
Performance Shares [Member]          
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized   $ 11,982,000     $ 11,982,000
Employee Stock Option [Member] | Incentive Plan [Member] | Vest 25% Each Year Until Fully Vested [Member]          
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage   25.00%      
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period   4 years      
Employee Stock Option [Member] | Incentive Plan [Member] | Non-employee Directors [Member]          
Share-based Compensation Arrangement by Share-based Payment Award, First Vesting Period After Grant Date   1 year      
Employee Stock Option [Member] | Incentive Plan [Member] | Minimum [Member]          
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term   5 years      
Employee Stock Option [Member] | Incentive Plan [Member] | Maximum [Member]          
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term   10 years      
Incentive Plan [Member]          
Allocated Share-based Compensation Expense   $ 5,840,000 $ 5,020,000    
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value | $ / shares   $ 8.21 $ 8.11    
Employee Stock Purchase Plan [Member]          
Allocated Share-based Compensation Expense   $ 94,000 $ 109,000    
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized | shares   1,475     1,475
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant | shares   519     519
Percentage of Salary to Purchase Common Stock, Maximum   15.00%      
Percentage of Common Stock Shares, Beginning   85.00%      
Percentage of Common Stock Shares, Ending   85.00%      
Share-based Compensation Arrangement by Share-based Payment Award, Maximum Number of Shares Per Employee | shares   3      
Shar-based Compensation Arrangement by Shar-based Payment Award, Maximum Number of Shares Per Employee, Amount   $ 25,000     $ 25,000
Stock Issued During Period, Shares, Employee Stock Purchase Plans | shares   20      
Allocated Share-based Compensation Expense   $ 5,934,000 $ 5,129,000    
Number of Stock-based Compensation Plans   2      
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant | shares   1,103   2,362 1,103