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Consolidated Statements of Comprehensive Income (Loss) (Unaudited) - USD ($)
shares in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2015
Jun. 30, 2014
Jun. 30, 2015
Jun. 30, 2014
Revenues        
Product sales, net     $ 537,000  
Royalty revenue $ 132,000 $ 125,000 1,650,000 $ 1,946,000
Collaborative and other research and development 25,710,000 1,341,000 30,481,000 2,978,000
Total revenues $ 25,842,000 $ 1,466,000 32,668,000 $ 4,924,000
Expenses        
Cost of products sold     15,000  
Research and development $ 16,524,000 $ 11,067,000 33,644,000 $ 20,250,000
General and administrative 3,534,000 2,013,000 7,595,000 3,601,000
Royalty 442,000 5,000 502,000 78,000
Total operating expenses 20,500,000 13,085,000 41,756,000 23,929,000
Income (loss) from operations 5,342,000 (11,619,000) (9,088,000) (19,005,000)
Interest and other income 116,000 19,000 233,000 36,000
Interest expense (1,306,000) (1,225,000) (2,621,000) (2,467,000)
Gain (loss) on foreign currency derivative 749,000 (1,824,000) 1,213,000 (3,350,000)
Net income (loss) $ 4,901,000 $ (14,649,000) $ (10,263,000) $ (24,786,000)
Basic net income (loss) per common share (in dollars per share) $ 0.07 $ (0.23) $ (0.14) $ (0.40)
Diluted net income (loss) per common share (in dollars per share) $ 0.06 $ (0.23) $ (0.14) $ (0.40)
Weighted average shares outstanding, basic (in shares) 72,642 63,647 72,492 61,629
Weighted average shares outstanding, diluted (in shares) 76,760 63,647 72,492 61,629
Unrealized gain (loss) on available for sale investments $ (102,000) $ 1,000 $ 38,000 $ (1,000)
Comprehensive income (loss) $ 4,799,000 $ (14,648,000) $ (10,225,000) $ (24,787,000)