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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
 6 Months Ended
Jun. 30, 2015
Jun. 30, 2014
Operating activities    
Net loss $ (10,263,000) $ (24,786,000)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:    
Depreciation and amortization 94,000 97,000
Stock-based compensation expense 5,934,000 5,129,000
Amortization of debt issuance costs 220,000 220,000
Change in fair value of foreign currency derivative 332,000 3,350,000
Changes in operating assets and liabilities:    
Receivables 5,194,000 $ 1,218,000
Inventory (625,000)  
Prepaid expenses and other assets 769,000 $ (408,000)
Deferred collaboration expense (136,000) 30,000
Accounts payable and accrued expenses 8,612,000 (247,000)
Interest payable (1,579,000) (81,000)
Deferred revenue 5,820,000 (583,000)
Net cash provided by (used in) operating activities 14,372,000 (16,061,000)
Investing activities    
Acquisitions of furniture and equipment (934,000) (7,000)
Change in restricted cash (1,419,000) 1,000
Purchases of investments (19,407,000) (12,651,000)
Sales and maturities of investments 24,884,000 20,900,000
Net cash provided by investing activities 3,124,000 8,243,000
Financing activities    
Sale of common stock, net 1,175,000 106,600,000
Exercise of stock options 3,399,000 4,145,000
Employee stock purchase plan sales $ 171,000 128,000
Payment of foreign currency derivative collateral   (2,700,000)
Net cash provided by financing activities $ 4,745,000 108,173,000
Increase in cash and cash equivalents 22,241,000 100,355,000
Cash and cash equivalents at beginning of period 54,540,000 21,164,000
Cash and cash equivalents at end of period $ 76,781,000 $ 121,519,000