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Sum of investments and unrestricted cash as of the balance sheet date.

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Amount before tax of reclassification adjustments of other comprehensive income (loss).

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Amount of revenue recognized from goods sold, services rendered, insurance premiums, or other activities that constitute an earning process. Includes, but is not limited to, investment and interest income before deduction of interest expense when recognized as a component of revenue, and sales and trading gain (loss).

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Note 1 - Significant Accounting Policies (Details Textual) - USD ($) shares in Thousands			1 Months Ended	3 Months Ended		9 Months Ended
	Mar. 03, 2015	Nov. 06, 2013	Jun. 30, 2015	Sep. 30, 2015	Sep. 30, 2014	Sep. 30, 2015	Sep. 30, 2014	Dec. 31, 2014	Mar. 09, 2011
Currency Hedge Agreement [Member]
Collateral Already Posted, Aggregate Fair Value				$ 0		$ 0		$ 0
Foreign Exchange Contract [Member] \| Not Designated as Hedging Instrument [Member]
Derivative, Loss on Derivative						793,000
Derivative, Gain on Derivative						1,654,000	$ 732,000
JPR Royalty Sub LLC [Member]
Revenue Recognition Royalty and Milestone Revenue Recognized									$ 30,000,000
Certificates of Deposit [Member]
Restricted Cash and Cash Equivalents, Current				150,000		150,000
Royalty Receivable [Member]
Restricted Cash and Cash Equivalents, Current				70,000		70,000
Collateral for Credit [Member]
Restricted Cash and Cash Equivalents				1,402,000		$ 1,402,000
Maximum [Member]
Maturity Period of High Quality Marketable Securities						3 years
Average Maturity Period of High Quality Marketable Securities						18 years
Maturity Period of Short Term Investment						12 years
Average Maturity for Portfolio Investments						1 year 180 days
Minimum [Member]
Maturity Period of Short Term Investment						3 years
Long-term Investment Maturity, Minimum						12 years
CSL [Member] \| Agreement [Member] \| RAPIVABMember \| Contingent upon EU Marketing Approval [Member]
Proceeds from License Fees Received			$ 7,000,000
CSL [Member] \| Agreement [Member] \| RAPIVABMember \| Revenue from Sale of Inventory to be Recognized When the Inventory Transfer Is Complete [Member]
Deferred Revenue, Additions			3,740,000
CSL [Member] \| Agreement [Member] \| RAPIVABMember \| Regulatory Support Revenue for Canadian and EU Marketing Approvals, Portion Recognized Ratably Over Expected Period of Involvement [Member]
Deferred Revenue, Additions			1,223,000
CSL [Member] \| Agreement [Member] \| RAPIVABMember
Proceeds from License Fees Received			33,740,000
Revenues			21,777,000
Milestone Payment Maximum			$ 12,000,000
RAPIVABMember \| Customer Concentration Risk [Member] \| Sales Revenue, Product Line [Member]
Concentration Risk, Percentage						90.00%
Loss on Sale of Investments						$ 0
Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax						13,000	0
Amortization of Financing Costs				110,000	$ 110,000	329,000	329,000
Investments and Cash				119,736,000		119,736,000
Securities Offered	$ 150,000,000	$ 10,000,000
Restricted Cash and Cash Equivalents, Current				1,622,000		1,622,000		$ 150,000
Revenues				10,987,000	3,238,000	43,655,000	8,162,000
Interest Expense				$ 1,241,000	$ 1,217,000	$ 3,862,000	$ 3,684,000
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount				3,821	4,240	3,673	3,986