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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
 9 Months Ended
Sep. 30, 2015
Sep. 30, 2014
Operating activities    
Net loss $ (24,884,000) $ (33,517,000)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:    
Depreciation and amortization 137,000 137,000
Stock-based compensation expense 7,773,000 6,550,000
Amortization of debt issuance costs 329,000 329,000
Change in fair value of foreign currency derivative 793,000 (732,000)
Changes in operating assets and liabilities:    
Receivables 1,995,000 $ (1,123,000)
Inventory 683,000
Prepaid expenses and other assets 1,331,000 $ (29,000)
Deferred collaboration expense (117,000) 45,000
Accounts payable and accrued expenses 12,582,000 3,602,000
Interest payable (512,000) 957,000
Deferred revenue 1,602,000 (880,000)
Net cash provided by (used in) operating activities 1,712,000 (24,661,000)
Investing activities    
Acquisitions of furniture and equipment (1,076,000) (41,000)
Change in restricted cash (1,472,000) 1,000
Purchases of investments (48,343,000) (15,852,000)
Sales and maturities of investments 35,874,000 29,000,000
Net cash (used in) provided by investing activities (15,017,000) 13,108,000
Financing activities    
Sale of common stock, net 1,175,000 106,600,000
Exercise of stock options 3,861,000 4,636,000
Employee stock purchase plan sales 356,000 310,000
Net cash provided by financing activities 5,392,000 111,546,000
(Decrease) Increase in cash and cash equivalents (7,913,000) 99,993,000
Cash and cash equivalents at beginning of period 54,540,000 21,164,000
Cash and cash equivalents at end of period $ 46,627,000 $ 121,157,000