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Note 7 - Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2015
Notes Tables |
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] |
|  | 2015 |  | 2014 |  | 2013
Income tax benefit at federal statutory rate (35%) |  | $ | (15,057 | ) |  | $ | (15,816 | ) |  | $ | (10,538 | )
State and local income taxes net of federal tax benefit |  |  | (819 | ) |  |  | (1,286 | ) |  |  | (839 | )
Permanent items |  |  | 560 |  |  |  | 258 |  |  |  | 738 |
Rate change |  |  | 1,012 |  |  |  | 22 |  |  |  | 1,892 |
Expiration of attribute carryforwards |  |  | 330 |  |  |  | 373 |  |  |  | 242 |
Research and development tax credits |  |  | (10,454 | ) |  |  | (748 | ) |  |  | (1,206 | )
Orphan drug credit |  |  | 4,307 |  |  |  | — |  |  |  | — |
Other |  |  | (218 | ) |  |  | (115 | ) |  |  | 1,144 |
Change in valuation allowance |  |  | 20,339 |  |  |  | 17,312 |  |  |  | 8,567 |
Income tax expense |  | $ | — |  |  | $ | — |  |  | $ | — |
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block] |
|  | 2015 |  | 2014
Balance at January 1, |  | $ | 472 |  |  | $ | 284 |
Additions to current period tax positions |  |  | 2,616 |  |  |  | 176 |
Additions to prior period tax positions |  |  | — |  |  |  | 12 |
Reductions to prior period tax provisions |  |  | (3 | ) |  |  | — |
Balance at December 31, |  | $ | 3,085 |  |  | $ | 472 |
Schedule of Deferred Tax Assets and Liabilities [Table Text Block] |
|  | 2015 |  | 2014
Deferred tax assets: |  |  |  |  |  |  |  |
Net federal and state operating losses |  | $ | 142,836 |  |  | $ | 135,922 |
Research and development credits |  |  | 48,551 |  |  |  | 38,096 |
Fixed assets |  |  | 1,054 |  |  |  | 1,073 |
Deferred revenue |  |  | 4,240 |  |  |  | 3,798 |
Stock-based compensation |  |  | 8,605 |  |  |  | 7,086 |
Other |  |  | 2,590 |  |  |  | 1,178 |
Total deferred tax assets |  |  | 207,876 |  |  |  | 187,153 |
Deferred tax liabilities: |  |  |  |  |  |  |  |
Foreign currency derivative |  |  | (2,668 | ) |  |  | (2,285 | )
Total deferred tax liabilities |  |  | (2,668 | ) |  |  | (2,285 | )
Valuation allowance |  |  | (205,208 | ) |  |  | (184,868 | )
Net deferred tax assets |  | $ | — |  |  | $ | — |

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