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Note 1 - Summary of Revenues (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
US Department of Health and Human Services [Member] |  |  |
Collaborative and other research and development revenues: |  |  |
Collaborative and other research and development revenues | $ 16,337 | $ 9,366 | $ 13,585
Green Cross Corporation [Member] |  |  |
Collaborative and other research and development revenues: |  |  |
Collaborative and other research and development revenues | 132 |  |
Shionogi and Co. Ltd [Member] |  |  |
Collaborative and other research and development revenues: |  |  |
Collaborative and other research and development revenues | 1,184 | $ 1,184 | $ 1,184
CSL [Member] |  |  |
Collaborative and other research and development revenues: |  |  |
Collaborative and other research and development revenues | 21,927 |  |
Product sales, net | 6,291 | $ 33 |
Royalty revenue | 2,386 | 3,025 | $ 2,562
Collaborative and other research and development revenues | 39,580 | 10,550 | 14,769
Revenues | $ 48,257 | $ 13,608 | $ 17,331

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