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Note 1 - Significant Accounting Policies and Concentrations of Risk (Tables) | 12 Months Ended
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Dec. 31, 2015
Notes Tables |
Available-for-sale Securities [Table Text Block] |
|  | December 31, 2015
|  | Amortized Cost |  | Accrued Interest |  | Gross Unrealized Gains |  | Gross Unrealized Losses |  | Estimated Fair Value
Obligations of U.S. Government and its agencies |  | $ | 26,557 |  |  | $ | 88 |  |  | $ | — |  |  | $ | (99 | ) |  | $ | 26,546 |
Corporate debt securities |  |  | 21,820 |  |  |  | 184 |  |  |  | — |  |  |  | (41 | ) |  |  | 21,963 |
Certificates of deposit |  |  | 21,884 |  |  |  | 21 |  |  |  | 5 |  |  |  | (72 | ) |  |  | 21,838 |
Total investments |  | $ | 70,261 |  |  | $ | 293 |  |  | $ | 5 |  |  | $ | (212 | ) |  | $ | 70,347 |
|  | December 31, 2014
|  | Amortized Cost |  | Accrued Interest |  | Gross Unrealized Gains |  | Gross Unrealized Losses |  | Estimated Fair Value
Obligations of U.S. Government and its agencies |  | $ | 20,307 |  |  | $ | 22 |  |  | $ | — |  |  | $ | (23 | ) |  | $ | 20,306 |
Corporate debt securities |  |  | 27,152 |  |  |  | 151 |  |  |  | 5 |  |  |  | (47 | ) |  |  | 27,261 |
Commercial paper |  |  | 11,838 |  |  |  | 6 |  |  |  | — |  |  |  | (63 | ) |  |  | 11,781 |
Total investments |  | $ | 59,297 |  |  | $ | 179 |  |  | $ | 5 |  |  | $ | (133 | ) |  | $ | 59,348 |
Available For Sale Securities Debt Maturities Fair Value [Table Text Block] |
|  | 2015 |  | 2014
Maturing in one year or less |  | $ | 22,664 |  |  | $ | 18,232 |
Maturing after one year through two years |  |  | 28,395 |  |  |  | 25,459 |
Maturing after two years |  |  | 19,288 |  |  |  | 15,657 |
Total investments |  | $ | 70,347 |  |  | $ | 59,348 |
Schedule of Receivables from Collaborations [Table Text Block] |
|  | December 31, 2015
|  | Billed |  | Unbilled |  | Total
U.S. Department of Health and Human Services |  | $ | — |  |  | $ | 5,536 |  |  | $ | 5,536 |
Shionogi & Co. Ltd. |  |  | 469 |  |  |  | — |  |  |  | 469 |
Seqirus UK Limited |  |  | 210 |  |  |  | 28 |  |  |  | 238 |
Total receivables |  | $ | 679 |  |  | $ | 5,564 |  |  | $ | 6,243 |
|  | December 31, 2014
|  | Billed |  | Unbilled |  | Total
U.S. Department of Health and Human Services |  | $ | — |  |  | $ | 2,778 |  |  | $ | 2,778 |
Shionogi & Co. Ltd. |  |  | 1,071 |  |  |  | — |  |  |  | 1,071 |
Total receivables |  | $ | 1,071 |  |  | $ | 2,778 |  |  | $ | 3,849 |
Schedule of Inventory, Current [Table Text Block] |
|  | As of December 31,
|  | 2015 |  | 2014
Work in process |  | $ | 1,612 |  |  | $ | 267 |
Finished goods |  |  | — |  |  |  | 416 |
Net inventories |  | $ | 1,612 |  |  | $ | 683 |
Schedule of Accrued Liabilities [Table Text Block] |
|  | December 31,
|  | 2015 |  | 2014
Compensation and benefits |  | $ | 424 |  |  | $ | 2,105 |
Development costs |  |  | 10,398 |  |  |  | 4,232 |
Inventory |  |  | 549 |  |  |  | 397 |
Professional fees |  |  | 242 |  |  |  | 238 |
Duties and taxes |  |  | 102 |  |  |  | 75 |
Other |  |  | 4,522 |  |  |  | 4,282 |
Total accrued expenses |  | $ | 16,237 |  |  | $ | 11,329 |
Schedule of Revenues from Collaborations [Table Text Block] |
|  | 2015 |  | 2014 |  | 2013
Product sales, net |  | $ | 6,291 |  |  | $ | 33 |  |  | $ | — |
Royalty revenue |  |  | 2,386 |  |  |  | 3,025 |  |  |  | 2,562 |
Collaborative and other research and development revenues: |  |  |  |  |  |  |  |  |  |  |  |
U.S. Department of Health and Human Services |  |  | 16,337 |  |  |  | 9,366 |  |  |  | 13,585 |
Green Cross Corporation |  |  | 132 |  |  |  | — |  |  |  | — |
Shionogi (Japan) |  |  | 1,184 |  |  |  | 1,184 |  |  |  | 1,184 |
Seqirus UK Limited |  |  | 21,927 |  |  |  | — |  |  |  | — |
Total collaborative and other research and development revenues |  |  | 39,580 |  |  |  | 10,550 |  |  |  | 14,769 |
Total revenues |  | $ | 48,257 |  |  | $ | 13,608 |  |  | $ | 17,331 |

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