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v3.3.1.900

Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Revenues |  |  |
Product sales, net | $ 6,291 | $ 33 |
Royalty revenue | 2,386 | 3,025 | $ 2,562
Collaborative and other research and development | 39,580 | 10,550 | 14,769
Total revenues | 48,257 | 13,608 | $ 17,331
Expenses |  |  |
Cost of products sold | 1,368 | 1 |
Research and development | 72,758 | 51,796 | $ 41,943
Selling, general and administrative | 13,047 | 7,461 | 6,007
Royalty | 528 | 121 | 98
Total operating expenses | 87,701 | 59,379 | 48,048
Loss from operations | (39,444) | (45,771) | (30,717)
Interest and other income | 535 | 93 | 93
Interest expense | (5,200) | (4,998) | (4,778)
Gain on foreign currency derivative | 1,090 | 5,487 | 5,294
Net loss | $ (43,019) | $ (45,189) | $ (30,108)
Basic and diluted net loss per common share (in dollars per share) | $ (0.59) | $ (0.68) | $ (0.55)
Weighted average shares outstanding (in shares) | 72,901 | 66,773 | 55,216
Unrealized loss on available for sale investments | $ (76) | $ (134) | $ (23)
Comprehensive loss | $ (43,095) | $ (45,323) | $ (30,131)

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