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Note 2 - Furniture and Equipment (Tables)
12 Months Ended
Dec. 31, 2015
Notes Tables  
Property, Plant and Equipment [Table Text Block]
    2015   2014
Furniture and fixtures   $ 718     $ 542  
Office equipment     1,122       1,115  
Software     1,427       1,423  
Laboratory equipment     6,004       5,786  
Leased equipment     63       63  
Leasehold improvements     5,610       5,303  
Construction in progress     2,821        
Building     1,589        
      19,354       14,232  
Less accumulated depreciation and amortization     (14,205 )     (14,025 )
Property and equipment, net   $ 5,149     $ 207