XML 47 R24.htm IDEA: XBRL DOCUMENT

Note 7 - Income Taxes (Tables)

12 Months Ended

Dec. 31, 2015

Notes Tables

Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]

		2015				2014				2013
Income tax benefit at federal statutory rate (35%)		$	(15,057	)		$	(15,816	)		$	(10,538	)
State and local income taxes net of federal tax benefit			(819	)			(1,286	)			(839	)
Permanent items			560				258				738
Rate change			1,012				22				1,892
Expiration of attribute carryforwards			330				373				242
Research and development tax credits			(10,454	)			(748	)			(1,206	)
Orphan drug credit			4,307				—				—
Other			(218	)			(115	)			1,144
Change in valuation allowance			20,339				17,312				8,567
Income tax expense		$	—			$	—			$	—

Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]

		2015				2014
Balance at January 1,		$	472			$	284
Additions to current period tax positions			2,616				176
Additions to prior period tax positions			—				12
Reductions to prior period tax provisions			(3	)			—
Balance at December 31,		$	3,085			$	472

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

		2015				2014
Deferred tax assets:
Net federal and state operating losses		$	142,836			$	135,922
Research and development credits			48,551				38,096
Fixed assets			1,054				1,073
Deferred revenue			4,240				3,798
Stock-based compensation			8,605				7,086
Other			2,590				1,178
Total deferred tax assets			207,876				187,153
Deferred tax liabilities:
Foreign currency derivative			(2,668	)			(2,285	)
Total deferred tax liabilities			(2,668	)			(2,285	)

Valuation allowance			(205,208	)			(184,868	)
Net deferred tax assets		$	—			$	—