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Consolidated Statements of Comprehensive Loss - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Revenues      
Product sales, net $ 6,291 $ 33
Royalty revenue 2,386 3,025 $ 2,562
Collaborative and other research and development 39,580 10,550 14,769
Total revenues 48,257 13,608 $ 17,331
Expenses      
Cost of products sold 1,368 1
Research and development 72,758 51,796 $ 41,943
Selling, general and administrative 13,047 7,461 6,007
Royalty 528 121 98
Total operating expenses 87,701 59,379 48,048
Loss from operations (39,444) (45,771) (30,717)
Interest and other income 535 93 93
Interest expense (5,200) (4,998) (4,778)
Gain on foreign currency derivative 1,090 5,487 5,294
Net loss $ (43,019) $ (45,189) $ (30,108)
Basic and diluted net loss per common share (in dollars per share) $ (0.59) $ (0.68) $ (0.55)
Weighted average shares outstanding (in shares) 72,901 66,773 55,216
Unrealized loss on available for sale investments $ (76) $ (134) $ (23)
Comprehensive loss $ (43,095) $ (45,323) $ (30,131)