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Note 7 - Income Taxes (Details Textual) - USD ($)	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Domestic Tax Authority [Member]
Operating Loss Carryforwards	$ 386,219,000
State and Local Jurisdiction [Member]
Operating Loss Carryforwards	373,454,000
Research Tax Credit Carryforward [Member]
Tax Credit Carryforward, Amount	48,551,000
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued	0	$ 0	$ 0
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount	20,339,000	$ 17,312,000	$ 8,567,000
Employee Service Share-based Compensation, Tax Benefit Realized from Exercise of Stock Options	$ 15,655,000

X

- Definition

Disclosure of the aggregate tax benefit realized from the exercise of stock options and the conversion of similar instruments during the annual period.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (j)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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- Definition

Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to increase (decrease) in the valuation allowance for deferred tax assets.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 12
-URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32687-109319

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Amount of operating loss carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.

+ References

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-Publisher FASB
-Name Accounting Standards Codification
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The amount of the tax credit carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.

+ References

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-Name Accounting Standards Codification
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-Publisher FASB
-Name Accounting Standards Codification
-Glossary Carryforwards
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Amount accrued for interest on an underpayment of income taxes and penalties related to a tax position claimed or expected to be claimed in the tax return.

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