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Note 2 - Furniture and Equipment
12 Months Ended
Dec. 31, 2015
Notes to Financial Statements  
Property, Plant and Equipment Disclosure [Text Block]
Note 2 — Property and Equipment
 
Property and equipment consisted of the following at December 31:
 
    2015   2014
Furniture and fixtures   $ 718     $ 542  
Office equipment     1,122       1,115  
Software     1,427       1,423  
Laboratory equipment     6,004       5,786  
Leased equipment     63       63  
Leasehold improvements     5,610       5,303  
Construction in progress     2,821        
Building     1,589        
      19,354       14,232  
Less accumulated depreciation and amortization     (14,205 )     (14,025 )
Property and equipment, net   $ 5,149     $ 207  
 
Depreciation and amortization expense for the years ended December 31, 2015, 2014 and 2013 was $180, $177 and $304, respectively.