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Consolidated Statements of Comprehensive Income (Loss) (Unaudited) - USD ($) shares in Thousands, $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2016 | Mar. 31, 2015
Revenues |  |
Product sales, net |  | $ 537
Royalty revenue | $ 1,890 | 1,518
Collaborative and other research and development | 2,930 | 4,771
Total revenues | $ 4,820 | 6,826
Expenses |  |
Cost of products sold |  | 15
Research and development | $ 20,579 | 17,120
General and administrative | 3,212 | 4,061
Royalty | 77 | 60
Total operating expenses | 23,868 | 21,256
Loss from operations | (19,048) | (14,430)
Interest and other income | 439 | 117
Interest expense | (1,470) | (1,315)
(Loss) gain on foreign currency derivative | (2,753) | 464
Net loss | $ (22,832) | $ (15,164)
Basic and diluted net loss per common share (in dollars per share) | $ (0.31) | $ (0.21)
Weighted average shares outstanding (in shares) | 73,601 | 72,341
Unrealized gain on available for sale investments | $ 254 | $ 140
Comprehensive loss | $ (22,578) | $ (15,024)

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- Definition Amount after tax of increase (decrease) in equity from transactions and other events and circumstances from net income and other comprehensive income, attributable to parent entity. Excludes changes in equity resulting from investments by owners and distributions to owners. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Other Comprehensive Income -URI http://asc.fasb.org/extlink&oid=51831270 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Comprehensive Income -URI http://asc.fasb.org/extlink&oid=51831223 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section 45 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=66004124&loc=d3e557-108580 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Net Income -URI http://asc.fasb.org/extlink&oid=51831255 + Details
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- Definition The amount of net income or loss for the period per each share in instances when basic and diluted earnings per share are the same amount and reported as a single line item on the face of the financial statements. Basic earnings per share is the amount of net income or loss for the period per each share of common stock or unit outstanding during the reporting period. Diluted earnings per share includes the amount of net income or loss for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period. + References No definition available. + Details
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