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Note 1 - Significant Accounting Policies and Concentrations of Risk (Tables) | 3 Months Ended
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Mar. 31, 2016
Notes Tables |
Available-for-sale Securities [Table Text Block] |
|  | March 31, 2016
|  | Amortized Cost |  | Accrued Interest |  | Gross Unrealized Gains |  | Gross Unrealized Losses |  | Estimated Fair Value
Obligations of the U.S. Government and its agencies |  | $ | 21,666 |  |  | $ | 53 |  |  | $ | 15 |  |  | $ | (6 | ) |  | $ | 21,728 |
Corporate debt securities |  |  | 20,718 |  |  |  | 94 |  |  |  | 23 |  |  |  | (3 | ) |  |  | 20,832 |
Certificates of deposit |  |  | 21,438 |  |  |  | 32 |  |  |  | 26 |  |  |  | (8 | ) |  |  | 21,488 |
Total investments |  | $ | 63,822 |  |  | $ | 179 |  |  | $ | 64 |  |  | $ | (17 | ) |  | $ | 64,048 |
|  | December 31, 2015
|  | Amortized Cost |  | Accrued Interest |  | Gross Unrealized Gains |  | Gross Unrealized Losses |  | Estimated Fair Value
Obligations of the U.S. Government and its agencies |  | $ | 26,557 |  |  | $ | 88 |  |  | $ | — |  |  | $ | (99 | ) |  | $ | 26,546 |
Corporate debt securities |  |  | 21,820 |  |  |  | 184 |  |  |  | — |  |  |  | (41 | ) |  |  | 21,963 |
Certificates of deposit |  |  | 21,884 |  |  |  | 21 |  |  |  | 5 |  |  |  | (72 | ) |  |  | 21,838 |
Total investments |  | $ | 70,261 |  |  | $ | 293 |  |  | $ | 5 |  |  | $ | (212 | ) |  | $ | 70,347 |
Available For Sale Securities Debt Maturities Fair Value [Table Text Block] |
|  | 2016 |  | 2015
Maturing in one year or less |  | $ | 22,914 |  |  | $ | 22,664 |
Maturing after one year through two years |  |  | 32,806 |  |  |  | 28,395 |
Maturing after two years |  |  | 8,328 |  |  |  | 19,288 |
Total investments |  | $ | 64,048 |  |  | $ | 70,347 |
Schedule of Receivables from Collaborations [Table Text Block] |
|  | March 31, 2016
|  | Billed |  | Unbilled |  | Total
U.S. Department of Health and Human Services |  | $ | 2,475 |  |  | $ | 2,734 |  |  | $ | 5,209 |
Shionogi & Co. Ltd. |  |  | 1,685 |  |  |  | — |  |  |  | 1,685 |
Seqirus UK Limited |  |  | 336 |  |  |  | 154 |  |  |  | 490 |
Total receivables |  | $ | 4,496 |  |  | $ | 2,888 |  |  | $ | 7,384 |
|  | December 31, 2015
|  | Billed |  | Unbilled |  | Total
U.S. Department of Health and Human Services |  | $ | — |  |  | $ | 5,536 |  |  | $ | 5,536 |
Shionogi & Co. Ltd. |  |  | 469 |  |  |  | — |  |  |  | 469 |
Seqirus UK Limited |  |  | 210 |  |  |  | 28 |  |  |  | 238 |
Total receivables |  | $ | 679 |  |  | $ | 5,564 |  |  | $ | 6,243 |
Schedule of Inventory, Current [Table Text Block] |
|  | 2016 |  | 2015
Work in process |  | $ | 1,949 |  |  | $ | 1,612 |
Inventories |  | $ | 1,949 |  |  | $ | 1,612 |
Schedule of Revenues from Collaborations [Table Text Block] |
|  | 2016 |  | 2015
Product sales, net |  | $ | — |  |  | $ | 537 |
Royalty revenue |  |  | 1,890 |  |  |  | 1,518 |
Collaborative and other research and development revenues: |  |  |  |  |  |  |  |
U.S. Department of Health and Human Services |  |  | 2,324 |  |  |  | 4,475 |
Shionogi & Co., Ltd. |  |  | 296 |  |  |  | 296 |
Seqirus UK Limited |  |  | 310 |  |  |  | — |
Total collaborative and other research and development revenues |  |  | 2,930 |  |  |  | 4,771 |
Total revenues |  | $ | 4,820 |  |  | $ | 6,826 |

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