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Note 1 - Significant Accounting Policies and Concentrations of Risk (Tables)

3 Months Ended

Mar. 31, 2016

Notes Tables

Available-for-sale Securities [Table Text Block]

		March 31, 2016
		Amortized Cost				Accrued Interest				Gross Unrealized Gains				Gross Unrealized Losses				Estimated Fair Value
Obligations of the U.S. Government and its agencies		$	21,666			$	53			$	15			$	(6	)		$	21,728
Corporate debt securities			20,718				94				23				(3	)			20,832
Certificates of deposit			21,438				32				26				(8	)			21,488
Total investments		$	63,822			$	179			$	64			$	(17	)		$	64,048

		December 31, 2015
		Amortized Cost				Accrued Interest				Gross Unrealized Gains				Gross Unrealized Losses				Estimated Fair Value
Obligations of the U.S. Government and its agencies		$	26,557			$	88			$	—			$	(99	)		$	26,546
Corporate debt securities			21,820				184				—				(41	)			21,963
Certificates of deposit			21,884				21				5				(72	)			21,838
Total investments		$	70,261			$	293			$	5			$	(212	)		$	70,347

Available For Sale Securities Debt Maturities Fair Value [Table Text Block]

		2016				2015
Maturing in one year or less		$	22,914			$	22,664
Maturing after one year through two years			32,806				28,395
Maturing after two years			8,328				19,288
Total investments		$	64,048			$	70,347

Schedule of Receivables from Collaborations [Table Text Block]

		March 31, 2016
		Billed				Unbilled				Total
U.S. Department of Health and Human Services		$	2,475			$	2,734			$	5,209
Shionogi & Co. Ltd.			1,685				—				1,685
Seqirus UK Limited			336				154				490
Total receivables		$	4,496			$	2,888			$	7,384

		December 31, 2015
		Billed				Unbilled				Total
U.S. Department of Health and Human Services		$	—			$	5,536			$	5,536
Shionogi & Co. Ltd.			469				—				469
Seqirus UK Limited			210				28				238
Total receivables		$	679			$	5,564			$	6,243

Schedule of Inventory, Current [Table Text Block]

		2016				2015
Work in process		$	1,949			$	1,612
Inventories		$	1,949			$	1,612

Schedule of Revenues from Collaborations [Table Text Block]

		2016				2015
Product sales, net		$	—			$	537
Royalty revenue			1,890				1,518
Collaborative and other research and development revenues:
U.S. Department of Health and Human Services			2,324				4,475
Shionogi & Co., Ltd.			296				296
Seqirus UK Limited			310				—
Total collaborative and other research and development revenues			2,930				4,771
Total revenues		$	4,820			$	6,826

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