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Note 3 - Collaborative and Other Research and Development Contracts (Details Textual) - USD ($)
$ in Thousands
 1 Months Ended 3 Months Ended 12 Months Ended
Jun. 16, 2015
Sep. 30, 2013
May. 31, 2010
Jun. 30, 2006
Feb. 28, 2006
Mar. 31, 2016
Dec. 31, 2015
Mar. 31, 2015
Base Contract [Member]                
Government Contract Receivable               $ 13,314
Additional Development Options [Member]                
Government Contract Receivable               22,855
ASPRBARDA Contract [Member]                
Government Contract Receivable               $ 36,169
Proceeds from awards for Research and Development Contracts           $ 17,623    
Green Cross Corporation [Member]                
Proceeds from License Fees Received       $ 250        
Mundipharma [Member]                
Upfront Payments Receivable Amount         $ 10,000      
AECOM and IRL [Member]                
Milestone Payment Maximum           4,000    
Milestone Payment Minimum           1,400    
Annual License Fee Minimum           150    
Annual License Fee Maximum           $ 500    
Advance Notice Period for Termination of Agreement           60 days    
Stock Issued During Period, Value, for Modification of License Agreement     $ 5,911          
Payments for Modification of License Agreement     $ 90          
National Institute of Allergy and Infectious Diseases [Member]                
Proceeds from awards for Research and Development Contracts   $ 5,000            
Expected Receivable From Awards for Research and Development Contracts             $ 34,002  
Collaborative Agreement Period of Contract             5 years  
Collaboration Agreement Additional Payments Received           $ 29,875    
UAB [Member]                
Period of Agreement           25 years    
Renewable Period of Agreement           5 years    
CSL Limited [Member                
Proceeds from License Fees Received $ 33,740              
Milestone Payment Maximum $ 12,000              
Royalty Term 10 years