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Consolidated Statements of Comprehensive Income (Loss) (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Revenues
Product sales, net		$ 537
Royalty revenue	$ 1,890	1,518
Collaborative and other research and development	2,930	4,771
Total revenues	$ 4,820	6,826
Expenses
Cost of products sold		15
Research and development	$ 20,579	17,120
General and administrative	3,212	4,061
Royalty	77	60
Total operating expenses	23,868	21,256
Loss from operations	(19,048)	(14,430)
Interest and other income	439	117
Interest expense	(1,470)	(1,315)
(Loss) gain on foreign currency derivative	(2,753)	464
Net loss	$ (22,832)	$ (15,164)
Basic and diluted net loss per common share (in dollars per share)	$ (0.31)	$ (0.21)
Weighted average shares outstanding (in shares)	73,601	72,341
Unrealized gain on available for sale investments	$ 254	$ 140
Comprehensive loss	$ (22,578)	$ (15,024)

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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