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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Operating activities    
Net loss $ (22,832,000) $ (15,164,000)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 47,000 45,000
Stock-based compensation expense 2,645,000 2,259,000
Amortization of Debt Issuance Costs 110,000 110,000
Change in fair value of foreign currency derivative 2,753,000 (464,000)
Changes in operating assets and liabilities:    
Receivables (1,141,000) 3,896,000
Inventory (337,000) (527,000)
Prepaid expenses and other assets (313,000) 1,848,000
Deferred collaboration expense 19,000 14,000
Accounts payable and accrued expenses (541,000) 3,404,000
Interest payable 1,228,000 1,212,000
Deferred revenue (480,000) (359,000)
Net cash used in operating activities (18,842,000) (3,726,000)
Investing activities    
Acquisitions of property and equipment (3,260,000) (565,000)
Change in restricted cash $ (353,000) (2,487,000)
Purchases of investments (3,378,000)
Sales and maturities of investments $ 6,320,000 2,482,000
Net cash provided by (used in) investing activities $ 2,707,000 (3,948,000)
Financing activities    
Sale of common stock, net 1,175,000
Net proceeds from common stock issued under stock-based compensation plans $ 7,000 $ 326,000
Increase in lease financing obligation 131,000
Net cash provided by financing activities 138,000 $ 1,501,000
Decrease in cash and cash equivalents (15,997,000) (6,173,000)
Cash and cash equivalents at beginning of period 28,899,000 54,540,000
Cash and cash equivalents at end of period $ 12,902,000 $ 48,367,000