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Consolidated Statements of Comprehensive (Loss) Income (Unaudited) - USD ($) shares in Thousands, $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2016 | Jun. 30, 2015 | Jun. 30, 2016 | Jun. 30, 2015
Revenues |  |  |  |
Product sales, net |  |  |  | $ 537
Royalty revenue | 629 | 132 | 2,519 | 1,650
Collaborative and other research and development | 4,158 | 25,710 | 7,088 | 30,481
Total revenues | 4,787 | 25,842 | 9,607 | 32,668
Expenses |  |  |  |
Cost of products sold |  |  |  | 15
Research and development | 14,166 | 16,524 | 34,745 | 33,644
General and administrative | 2,724 | 3,534 | 5,936 | 7,595
Royalty | 27 | 442 | 104 | 502
Total operating expenses | 16,917 | 20,500 | 40,785 | 41,756
(Loss) income from operations | (12,130) | 5,342 | (31,178) | (9,088)
Interest and other income | 147 | 116 | 586 | 233
Interest expense | (1,421) | (1,306) | (2,891) | (2,621)
(Loss) gain on foreign currency derivative | (2,877) | 749 | (5,630) | 1,213
Net (loss) income | $ (16,281) | $ 4,901 | $ (39,113) | $ (10,263)
Basic net (loss) income per common share (in dollars per share) | $ (0.22) | $ 0.07 | $ (0.53) | $ (0.14)
Diluted net (loss) income per common share (in dollars per share) | $ (0.22) | $ 0.06 | $ (0.53) | $ (0.14)
Weighted average shares outstanding, basic (in shares) | 73,695 | 72,642 | 73,648 | 72,492
Weighted average shares outstanding, diluted (in shares) | 73,695 | 76,760 | 73,648 | 72,492
Unrealized (loss) gain on available for sale investments | $ (2) | $ (102) | $ 252 | $ 38
Comprehensive (loss) income | $ (16,283) | $ 4,799 | $ (38,861) | $ (10,225)

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- Definition Amount after tax of increase (decrease) in equity from transactions and other events and circumstances from net income and other comprehensive income, attributable to parent entity. Excludes changes in equity resulting from investments by owners and distributions to owners. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Other Comprehensive Income -URI http://asc.fasb.org/extlink&oid=51831270 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Comprehensive Income -URI http://asc.fasb.org/extlink&oid=51831223 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section 45 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=66004124&loc=d3e557-108580 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Net Income -URI http://asc.fasb.org/extlink&oid=51831255 + Details
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