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Note 1 - Summary of Revenues (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Jun. 30, 2016
Jun. 30, 2015
US Department of Health and Human Services [Member]        
Collaborative and other research and development revenues $ 3,709 $ 3,731 $ 6,033 $ 8,206
Shionogi and Co. Ltd [Member]        
Collaborative and other research and development revenues 296 296 592 592
Seqirus UK Limited [Member]        
Collaborative and other research and development revenues 153 21,683 463 21,683
Product sales, net 537
Royalty revenue 629 132 2,519 1,650
Collaborative and other research and development revenues 4,158 25,710 7,088 30,481
Revenues $ 4,787 $ 25,842 $ 9,607 $ 32,668