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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
 6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Operating activities    
Net loss $ (39,113,000) $ (10,263,000)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 136,000 94,000
Stock-based compensation expense 4,491,000 5,934,000
Amortization of Debt Issuance Costs 220,000 220,000
Amortization of premium/discount on investments 302,000 266,000
Change in fair value of foreign currency derivative 6,441,000 332,000
Changes in operating assets and liabilities:    
Receivables 4,009,000 5,194,000
Inventory (337,000) (625,000)
Prepaid expenses and other assets 1,000,000 503,000
Deferred collaboration expense 37,000 (136,000)
Accounts payable and accrued expenses (8,742,000) 8,612,000
Interest payable 2,457,000 (1,579,000)
Deferred revenue (927,000) 5,820,000
Net cash (used in) provided by operating activities (30,026,000) 14,372,000
Investing activities    
Acquisitions of property and equipment (5,099,000) (934,000)
Change in restricted cash (2,814,000) (1,419,000)
Purchases of investments (19,407,000)
Sales and maturities of investments 19,064,000 24,884,000
Net cash provided by investing activities 11,151,000 3,124,000
Financing activities    
Sale of common stock, net 1,175,000
Net proceeds from common stock issued under stock-based compensation plans 33,000 3,570,000
Payment of foreign currency derivative collateral (1,610,000)
Increase in lease financing obligation 214,000
Net cash (used in) provided by financing activities (1,363,000) 4,745,000
(Decrease) increase in cash and cash equivalents (20,238,000) 22,241,000
Cash and cash equivalents at beginning of period 28,899,000 54,540,000
Cash and cash equivalents at end of period $ 8,661,000 $ 76,781,000