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Note 1 - Significant Accounting Policies (Details Textual)
shares in Thousands
 1 Months Ended 3 Months Ended 9 Months Ended
Jun. 30, 2015
USD ($)
Sep. 30, 2016
USD ($)
shares
Mar. 31, 2016
USD ($)
Sep. 30, 2015
USD ($)
shares
Sep. 30, 2016
USD ($)
shares
Sep. 30, 2015
USD ($)
shares
Sep. 26, 2016
USD ($)
Sep. 23, 2016
USD ($)
Dec. 31, 2015
USD ($)
Mar. 09, 2011
USD ($)
Customer Concentration Risk [Member] | Sales Revenue, Product Line [Member] | RAPIVAB [Member] | Three Customers [Member]                    
Concentration Risk, Percentage         90.00%          
Customer Concentration Risk [Member] | Sales Revenue, Product Line [Member] | RAPIVAB [Member]                    
Number of Major Customers         3          
RAPIVAB [Member] | Agreement [Member] | CSL [Member] | Contingent upon EU Marketing Approval [Member]                    
Proceeds from License Fees Received $ 7,000,000                  
RAPIVAB [Member] | Agreement [Member] | CSL [Member] | Regulatory Support Revenue for Canadian and EU Marketing Approvals, Portion Recognized Ratably Over Expected Period of Involvement [Member]                    
Deferred Revenue, Additions 1,223,000                  
RAPIVAB [Member] | Agreement [Member] | CSL [Member]                    
Proceeds from License Fees Received 33,740,000                  
Revenues 21,777,000                  
Milestone Payment Maximum 12,000,000                  
JPR Royalty Sub LLC [Member]                    
Revenue Recognition Royalty and Milestone Revenue Recognized                   $ 30,000,000
Senior Credit Facility [Member] | MidCap Financial Services, LLC [Member]                    
Long-term Line of Credit   $ 23,000,000     $ 23,000,000   $ 23,000,000 $ 23,000,000    
Debt Issuance Costs Reclassifed from Other Current Assets [Member] | December 31, 2015 [Member]                    
Prior Period Reclassification Adjustment     $ 2,196,000              
Royalty Receivable [Member]                    
Restricted Cash and Cash Equivalents, Current   101,000     101,000          
Collateral for Credit [Member]                    
Restricted Cash and Cash Equivalents, Current   1,405,000     $ 1,405,000          
Maximum [Member]                    
Maturity Period of High Quality Marketable Securities         3 years          
Average Maturity Period of High Quality Marketable Securities         1 year 180 days          
Maturity Period of Short Term Investment         1 year          
Average Maturity for Portfolio Investments         1 year 180 days          
Minimum [Member]                    
Maturity Period of Short Term Investment         90 days          
Long-term Investment Maturity, Minimum         1 year          
Computer Equipment [Member]                    
Property, Plant and Equipment, Useful Life         3 years          
Laboratory Equipment, Office Equipment and Software [Member]                    
Property, Plant and Equipment, Useful Life         5 years          
Furniture and Fixtures [Member]                    
Property, Plant and Equipment, Useful Life         7 years          
Leasehold Improvements [Member] | Birmingham Research Facility [Member]                    
Property, Plant and Equipment, Useful Life         20 years 182 days          
Property, Plant and Equipment, Gross   1,589,000     $ 1,589,000          
Lease Financing Obligation, Net of Current   2,675,000     2,675,000          
Foreign Exchange Contract [Member] | Not Designated as Hedging Instrument [Member]                    
Deferred Revenue, Additions $ 3,740,000                  
Derivative, Loss on Derivative         7,372,000 $ 793,000        
Derivative, Gain on Derivative         811,000 1,654,000        
Currency Hedge Agreement [Member]                    
Collateral Already Posted, Aggregate Fair Value   2,190,000     2,190,000       $ 0  
PhaRMA Notes Member]                    
Interest Expense   1,465,000   $ 1,241,000 4,356,000 3,862,000        
Birmingham Research Facility [Member]                    
Interest Expense   86,000     300,000          
Capital Leases, Future Minimum Payments Due   4,839,000     4,839,000          
Investments and Cash   68,698,000     68,698,000          
Loss on Sale of Investments         0          
Long-term Line of Credit   22,665,000     $ 22,665,000        
Maturity of Investments         3 years          
Restricted Cash and Cash Equivalents, Current   1,506,000     $ 1,506,000       1,612,000  
Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax         11,000 13,000        
Revenues   7,763,000   10,987,000 17,370,000 43,655,000        
Interest Expense   1,465,000   1,241,000 4,356,000 3,862,000        
Amortization of Debt Issuance Costs   116,000   $ 110,000 335,000 $ 329,000        
Lease Financing Obligation, Net of Current   $ 2,675,000     $ 2,675,000       $ 2,375,000  
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount | shares   1,291   3,821 1,190 3,673