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Note 1 - Significant Accounting Policies - Summary of Revenues (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
US Department of Health and Human Services [Member]        
Collaborative and other research and development revenues $ 3,813 $ 4,582 $ 9,846 $ 12,788
Green Cross Corporation [Member]        
Collaborative and other research and development revenues 132 132
Shionogi and Co. Ltd [Member]        
Collaborative and other research and development revenues 296 296 888 888
Seqirus UK Limited [Member]        
Collaborative and other research and development revenues 153 152 616 21,835
Product sales, net 5,699 6,236
Royalty revenue 3,501 126 6,020 1,776
Collaborative and other research and development revenues 4,262 5,162 11,350 35,643
Revenues $ 7,763 $ 10,987 $ 17,370 $ 43,655