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Consolidated Statements of Comprehensive (Loss) Income (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Revenues
Product sales, net		$ 5,699		$ 6,236
Royalty revenue	3,501	126	6,020	1,776
Collaborative and other research and development	4,262	5,162	11,350	35,643
Total revenues	7,763	10,987	17,370	43,655
Expenses
Cost of products sold		1,346		1,361
Research and development	14,105	20,067	48,850	53,711
General and administrative	2,756	2,731	8,692	10,326
Royalty	143	5	247	507
Total operating expenses	17,004	24,149	57,789	65,905
Loss from operations	(9,241)	(13,162)	(40,419)	(22,250)
Interest and other income	109	134	695	367
Interest expense	(1,465)	(1,241)	(4,356)	(3,862)
(Loss) gain on foreign currency derivative	(931)	(352)	(6,561)	861
Net loss	$ (11,528)	$ (14,621)	$ (50,641)	$ (24,884)
Basic and diluted net loss per common share (in dollars per share)	$ (0.16)	$ (0.20)	$ (0.69)	$ (0.34)
Weighted average shares outstanding (in shares)	73,734	73,262	73,677	72,752
Unrealized (loss) gain on available for sale investments	$ (24)	$ 91	$ 228	$ 129
Comprehensive loss	$ (11,552)	$ (14,530)	$ (50,413)	$ (24,755)

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