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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
 9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Operating activities    
Net loss $ (50,641,000) $ (24,884,000)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 311,000 137,000
Loss on disposal of property and equipment 21,000
Stock-based compensation expense 6,478,000 7,773,000
Amortization of Debt Issuance Costs 335,000 329,000
Amortization of premium/discount on investments 499,000 459,000
Change in fair value of foreign currency derivative 7,372,000 793,000
Changes in operating assets and liabilities:    
Receivables 275,000 1,995,000
Inventory (620,000) 683,000
Prepaid expenses and other assets 667,000 872,000
Deferred collaboration expense 43,000 (117,000)
Accounts payable and accrued expenses (12,066,000) 12,582,000
Interest payable 817,000 (512,000)
Deferred revenue (1,075,000) 1,602,000
Net cash (used in) provided by operating activities (47,584,000) 1,712,000
Investing activities    
Acquisitions of property and equipment (5,278,000) (1,076,000)
Change in restricted cash 106,000 (1,472,000)
Purchases of investments (48,343,000)
Sales and maturities of investments 38,272,000 35,874,000
Net cash provided by (used in) investing activities 33,100,000 (15,017,000)
Financing activities    
Sale of common stock, net 1,175,000
Net proceeds from common stock issued under stock-based compensation plans 204,000 4,217,000
Proceeds from senior credit facility 22,658,000
Payment of foreign currency derivative collateral (2,190,000)
Increase in lease financing obligation 300,000
Net cash provided by financing activities 20,972,000 5,392,000
Increase (decrease) in cash and cash equivalents 6,488,000 (7,913,000)
Cash and cash equivalents at beginning of period 28,899,000 54,540,000
Cash and cash equivalents at end of period $ 35,387,000 $ 46,627,000