<SEC-DOCUMENT>0001171843-16-009165.txt : 20160516
<SEC-HEADER>0001171843-16-009165.hdr.sgml : 20160516
<ACCEPTANCE-DATETIME>20160414160011
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ACCESSION NUMBER:		0001171843-16-009165
CONFORMED SUBMISSION TYPE:	CORRESP
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20160414

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIOCRYST PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000882796
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				621413174
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		CORRESP

	BUSINESS ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703
		BUSINESS PHONE:		919-859-1302

	MAIL ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703
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<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">BioCryst Pharmaceuticals, Inc.</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">4505 Emperor Blvd., Suite 200</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">Durham, North Carolina 27703</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">(919) 859-1302</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">April 14, 2016</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: left; margin: 0pt 0"><U>VIA EDGAR</U></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">Securities and Exchange Commission<BR>
Division of Corporation Finance<BR>
100 F Street, N.E.<BR>
Washington, DC 20549<BR>
Attn: Mary Beth Breslin</P>

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<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in"><B>Re:</B></TD><TD STYLE="padding-right: 0.5in"><B><I>BioCryst Pharmaceuticals, Inc.</I><BR>
<I>Post-Effective Amendment No. 1 to Registration Statement on Form S-3 Filed February 26, 2016</I><BR>
<I>(File No.&nbsp;333-202466)</I></B></TD></TR></TABLE>

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<P STYLE="font-size: 10pt; margin: 0pt 0">Ladies and Gentlemen:</P>

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<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0">Pursuant to Rule&nbsp;461 promulgated under the Securities Act of
1933, as amended, BioCryst Pharmaceuticals, Inc., a Delaware corporation (the &ldquo;Company&rdquo;), hereby respectfully requests
that the effective time of the above referenced Post-Effective Amendment No. 1 to Registration Statement on Form S-3 filed by the
Company (the &ldquo;Registration Statement&rdquo;) be accelerated to 4:00 p.m., Eastern Daylight Time, on April 18, 2016 or as
soon thereafter as practicable.</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0">The Company hereby acknowledges that:</P>

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<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT></TD><TD>should the Securities and Exchange Commission (the &ldquo;Commission&rdquo;) or the staff, acting pursuant to delegated authority,
declare the Registration Statement effective, it does not foreclose the Commission from taking any action with respect to the Registration
Statement;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

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<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT></TD><TD>the action of the Commission or the staff, acting pursuant to delegated authority, in declaring the Registration Statement
effective, does not relieve the Company from its full responsibility for the adequacy and accuracy of the disclosure in the Registration
Statement; and</TD></TR></TABLE>

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<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT></TD><TD>the Company may not assert staff comments and the declaration of effectiveness as a defense in any proceeding initiated by
the Commission or any person under the federal securities laws of the United States.</TD></TR></TABLE>

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<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">[Signature page follows]</P>

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<P STYLE="font-size: 10pt; margin: 0pt 0 0pt 2.5in">Very truly yours,</P>

<P STYLE="font-size: 10pt; margin: 0pt 0 0pt 2.5in">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0 0pt 2.5in">BioCryst Pharmaceuticals, Inc.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0 0pt 2.5in">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0 0pt 2.5in"><U>/s/ Alane Barnes&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U></P>

<P STYLE="font-size: 10pt; margin: 0pt 0 0pt 2.5in">Alane Barnes<BR>
Vice President, General Counsel and Corporate Secretary</P>

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<TD STYLE="width: 35pt; text-align: left">cc:</TD><TD STYLE="width: 5pt"></TD><TD STYLE="text-align: justify">Brian Lane, Gibson, Dunn &amp; Crutcher LLP</TD>
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