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Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
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Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Revenues |  |  |
Product sales, net | $ 2,269 | $ 6,291 | $ 33
Royalty revenue | 9,682 | 2,386 | 3,025
Collaborative and other research and development | 14,402 | 39,580 | 10,550
Total revenues | 26,353 | 48,257 | 13,608
Expenses |  |  |
Cost of products sold | 2,297 | 1,368 | 1
Research and development | 61,008 | 72,758 | 51,796
Selling, general and administrative | 11,253 | 13,047 | 7,461
Royalty | 402 | 528 | 121
Total operating expenses | 74,960 | 87,701 | 59,379
Loss from operations | (48,607) | (39,444) | (45,771)
Interest and other income | 793 | 535 | 93
Interest expense | (6,487) | (5,200) | (4,998)
(Loss) gain on foreign currency derivative | (843) | 1,090 | 5,487
Net loss | $ (55,144) | $ (43,019) | $ (45,189)
Basic and diluted net loss per common share (in dollars per share) | $ (0.75) | $ (0.59) | $ (0.68)
Weighted average shares outstanding (in shares) | 73,699 | 72,901 | 66,773
Unrealized gain (loss) on available for sale investments | $ 194 | $ (76) | $ (134)
Comprehensive loss | $ (54,950) | $ (43,095) | $ (45,323)

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