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Note 1 - Significant Accounting Policies and Concentration of Risk - Summary of Revenues (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Product sales, net | $ 2,269 | $ 6,291 | $ 33
Royalty revenue | 9,682 | 2,386 | 3,025
Collaborative and other research and development revenues | 14,402 | 39,580 | 10,550
Revenues | 26,353 | 48,257 | 13,608
US Department of Health and Human Services [Member] |  |  |
Collaborative and other research and development revenues | 12,449 | 16,337 | 9,366
Green Cross Corporation [Member] |  |  |
Collaborative and other research and development revenues |  | 132 |
Shionogi and Co. Ltd [Member] |  |  |
Collaborative and other research and development revenues | 1,184 | 1,184 | 1,184
Seqirus UK Limited [Member] |  |  |
Collaborative and other research and development revenues | $ 769 | $ 21,927 |

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