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Note 8 - Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2016
Notes Tables |
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] |
|  | 2016 |  | 2015 |  | 2014
Income tax benefit at federal statutory rate (35%) |  | $ | (19,300 | ) |  | $ | (15,057 | ) |  | $ | (15,816 | )
State and local income taxes net of federal tax benefit |  |  | (1,173 | ) |  |  | (819 | ) |  |  | (1,286 | )
Permanent items |  |  | 1,057 |  |  |  | 560 |  |  |  | 258 |
Rate change |  |  | 1,080 |  |  |  | 1,012 |  |  |  | 22 |
Expiration of attribute carryforwards |  |  | 559 |  |  |  | 330 |  |  |  | 373 |
Research and development tax credits |  |  | (4,681 | ) |  |  | (10,454 | ) |  |  | (748 | )
Orphan drug credit |  |  | 1,798 |  |  |  | 4,307 |  |  |  | — |
Other |  |  | 822 |  |  |  | (218 | ) |  |  | (115 | )
Change in valuation allowance |  |  | 19,838 |  |  |  | 20,339 |  |  |  | 17,312 |
Income tax expense |  | $ | — |  |  | $ | — |  |  | $ | — |
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block] |
|  | 2016 |  | 2015
Balance at January 1, |  | $ | 3,085 |  |  | $ | 472 |
Additions to current period tax positions |  |  | 1,170 |  |  |  | 2,616 |
Additions to prior period tax positions |  |  | — |  |  |  | — |
Reductions to prior period tax provisions |  |  | — |  |  |  | (3 | )
Balance at December 31, |  | $ | 4,255 |  |  | $ | 3,085 |
Schedule of Deferred Tax Assets and Liabilities [Table Text Block] |
|  | 2016 |  | 2015
Deferred tax assets: |  |  |  |  |  |  |  |
Net federal and state operating losses |  | $ | 158,618 |  |  | $ | 142,836 |
Research and development credits |  |  | 53,231 |  |  |  | 48,551 |
Fixed assets |  |  | — |  |  |  | 1,054 |
Deferred revenue |  |  | 3,484 |  |  |  | 4,240 |
Stock-based compensation |  |  | 8,952 |  |  |  | 8,605 |
Other |  |  | 2,849 |  |  |  | 2,590 |
Total deferred tax assets |  |  | 227,134 |  |  |  | 207,876 |
Deferred tax liabilities: |  |  |  |  |  |  |  |
Fixed assets |  |  | (674 | ) |  |  | — |
Foreign currency derivative |  |  | (1,415 | ) |  |  | (2,668 | )
Total deferred tax liabilities |  |  | (2,089 | ) |  |  | (2,668 | )
Valuation allowance |  |  | (225,045 | ) |  |  | (205,208 | )
Net deferred tax assets |  | $ | — |  |  | $ | — |

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