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v3.6.0.2

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Operating activities: |  |  |
Net loss | $ (55,144) | $ (43,019) | $ (45,189)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation, amortization, and impairment | 483 | 180 | 177
Loss on disposal of property and equipment | 17 |  | 27
Stock-based compensation expense | 8,487 | 9,705 | 10,177
Amortization of Debt Issuance Costs | 558 | 439 | 439
Amortization of premium/discount on investments | 523 | 570 | 150
Change in fair value of foreign currency derivative | (811) | 564 | (5,487)
Changes in operating assets and liabilities: |  |  |
Receivables | (2,525) | 3,247 | (7,375)
Inventory | 1,112 | (929) | (683)
Prepaid expenses and other assets | 3,702 | 637 | (2,093)
Deferred collaboration expense | 71 | (102) | 59
Accounts payable and accrued expenses | (10,524) | 13,676 | 4,656
Interest payable | 2,244 | 717 | 2,162
Deferred revenue | (1,631) | 1,199 | 4,429
Net cash used in operating activities: | (53,438) | (13,116) | (38,551)
Investing activities: |  |  |
Acquisition of property and equipment | (5,277) | (5,122) | (106)
Proceeds from sale of property and equipment | 4 |  |
Change in restricted cash | 66 | (1,462) | 1
Purchases of investments | (14,106) | (53,830) | (73,875)
Sales and maturities of investments | 42,652 | 42,410 | 34,000
Net cash provided (used) in investing activities: | 23,339 | (18,004) | (39,980)
Financing activities: |  |  |
Sale of common stock, net |  |  | 106,600
Net proceeds from common stock issued under stock-based compensation plans | 317 | 5,479 | 5,307
Proceeds from senior credit facility | 22,658 |  |
Increase in lease financing obligation | 329 |  |
Net cash provided by financing activities: | 23,304 | 5,479 | 111,907
(Decrease) increase in cash and cash equivalents | (6,795) | (25,641) | 33,376
Cash and cash equivalents at beginning of year | 28,899 | 54,540 | 21,164
Cash and cash equivalents at end of year | $ 22,104 | $ 28,899 | $ 54,540

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- Definition The cash inflow associated with the amount received from holders exercising their stock options. This item inherently excludes any excess tax benefit, which the entity may have realized and reported separately. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (j) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration