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Note 8 - Income Taxes - Components of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2016 | Dec. 31, 2015
--- | --- | ---
Deferred tax assets: |  |
Net federal and state operating losses | $ 158,618 | $ 142,836
Research and development credits | 53,231 | 48,551
Fixed assets |  | 1,054
Deferred revenue | 3,484 | 4,240
Stock-based compensation | 8,952 | 8,605
Other | 2,849 | 2,590
Total deferred tax assets | 227,134 | 207,876
Fixed assets | (674) |
Foreign currency derivative | (1,415) | (2,668)
Total deferred tax liabilities | (2,089) | (2,668)
Valuation allowance | (225,045) | (205,208)
Net deferred tax assets |  |

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