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Note 3 - Royalty Monetization (Details Textual) $ in Thousands |  | 1 Months Ended | 9 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | ---
Mar. 09, 2011 USD ($) | Aug. 31, 2014 USD ($) | Jun. 30, 2014 USD ($) | Mar. 31, 2014 USD ($) | Sep. 30, 2013 USD ($) | Sep. 30, 2015 USD ($) | Dec. 31, 2016 USD ($) | Dec. 31, 2015 USD ($) | Dec. 31, 2014 USD ($) | Dec. 31, 2014 JPY (¥) | Sep. 30, 2014 USD ($) | Sep. 03, 2013 USD ($)
Foreign Exchange Contract [Member] | Not Designated as Hedging Instrument [Member] |  |  |  |  |  |  |  |  |  |  |  |
Derivative, Loss on Derivative |  |  |  |  |  |  | $ 1,654 | $ 564 |  |  |  |
Derivative, Gain on Derivative |  |  |  |  |  |  | $ 811 | $ 1,654 | $ 5,487 |  |  |
PhaRMA Notes Member] | Currency Hedge Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Payments for (Proceeds from) Hedge, Investing Activities |  |  |  |  |  | $ 1,950 |  |  |  |  |  |
Required Foreign Currency Hedge Per Dollar | ¥ |  |  |  |  |  |  |  |  |  | ¥ 100 |  |
PhaRMA Notes Member] | Japan, Yen | Currency Hedge Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Derivative, Forward Exchange Rate |  |  |  |  |  | 100 |  |  |  |  |  |
JPR Royalty Sub LLC [Member] | PhaRMA Notes Member] |  |  |  |  |  |  |  |  |  |  |  |
Private Placement of Senior Secured Notes | $ 30,000 |  |  |  |  |  |  |  |  |  |  |
Debt Instrument, Interest Rate, Stated Percentage | 14.00% |  |  |  | 14.00% |  |  |  |  |  |  |
Interest Paid |  | $ 70 | $ 1,882 | $ 446 | $ 1,844 |  |  |  |  |  |  |
Interest Payable |  |  |  |  |  |  |  |  |  |  |  | $ 2,356
Percentage of Carrying Amount in Excess of Fair Value |  |  |  |  |  |  | 50.00% |  |  |  |  |
JPR Royalty Sub LLC [Member] | PhaRMA Notes Member] | Currency Hedge Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Maximum Amount of Collateral Required to Post |  |  |  |  |  |  | $ 7,800 |  |  |  |  |
JPR Royalty Sub LLC [Member] | PhaRMA Notes Member] | Fair Value, Inputs, Level 2 [Member] |  |  |  |  |  |  |  |  |  |  |  |
Notes Payable, Fair Value Disclosure |  |  |  |  |  |  | $ 30,000 |  |  |  |  |
JPR Royalty Sub LLC [Member] | PhaRMA Notes Member] | Shortfall 2013 [Member] |  |  |  |  |  |  |  |  |  |  |  |
Interest Payable |  |  |  |  |  |  |  |  |  |  | $ 222 |
JPR Royalty Sub LLC [Member] | Royalty Monetization [Member] |  |  |  |  |  |  |  |  |  |  |  |
Revenue Recognition Royalty and Milestone Revenue Recognized | $ 30,000 |  |  |  |  |  |  |  |  |  |  |
Revenue Recognition Royalty And Milestone Revenue Recognized, Net | 22,691 |  |  |  |  |  |  |  |  |  |  |
Transaction Costs | 4,309 |  |  |  |  |  |  |  |  |  |  |
Interest Reserve | $ 3,000 |  |  |  |  |  |  |  |  |  |  |

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