XML 45 R25.htm IDEA: XBRL DOCUMENT v3.6.0.2
Note 7 - Share-Based Compensation (Tables)
 12 Months Ended
Dec. 31, 2016
Notes Tables  
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]
    Year Ended December 31,
    2016   2015   2014
Research and development   $
6,088
     $
7,580
     $
8,906
  
General and administrative    
2,399
      
2,125
      
1,271
  
Total stock-based compensation expense   $
8,487
     $
9,705
     $
10,177
  
Schedule of Share-based Compensation, Activity [Table Text Block]
    Awards
Available		   Options
Outstanding		   Weighted
Average
Exercise
Price
Balance at December 31, 2013    
1,082
      
8,986
     $
4.99
  
Plan amendment    
3,750
      
—
      
—
  
Restricted stock awards granted    
(593
 )    
—
      
—
  
Restricted stock awards cancelled    
—
      
—
      
—
  
Stock option awards granted    
(1,965
 )    
1,965
      
10.99
  
Stock option awards exercised    
—
      
(1,258
 )    
4.78
  
Stock option awards cancelled    
88
      
(88
 )    
8.83
  
Balance at December 31, 2014    
2,362
      
9,605
      
6.21
  
Restricted stock awards granted    
(163
 )    
—
      
—
  
Restricted stock awards cancelled    
1
      
—
      
—
  
Stock option awards granted    
(2,217
 )    
2,217
      
11.52
  
Stock option awards exercised    
—
      
(1,118
 )    
4.36
  
Stock option awards cancelled    
33
      
(33
 )    
9.87
  
Balance at December 31, 2015    
16
      
10,671
      
7.50
  
Plan amendment    
3,800
      
 
      
 
  
Restricted stock awards granted    
(34
 )    
—
      
—
  
Restricted stock awards cancelled    
22
      
—
      
—
  
Stock option awards granted    
(2,248
 )    
2,248
      
3.20
  
Stock option awards exercised    
—
      
(107
 )    
2.63
  
Stock option awards cancelled    
717
      
(717
 )    
10.78
  
Balance at December 31, 2016    
2,273
      
12,095
     $
6.55
  
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
    2016   2015   2014
Expected Life    
5.5
      
5.5
      
5.5
  
Expected Volatility    
82
 %    
81
 %    
87
 %
Expected Dividend Yield    
0.0
 %    
0.0
 %    
0.0
 %
Risk-Free Interest Rate    
1.4
 %    
1.6
 %    
1.6
 %
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding and Exercisable [Table Text Block]
 
 
 
 
 
Outstanding
 
Exercisable
Range
 
 
 
Number
 
Weighted
Average
Remaining
Life
 
Weighted
Average
Exercise
Price
 
Number
 
Weighted
Average
Exercise
Price
$
0
to
3
 
1,919
 
 
5.7
 
 
$
1.64
 
 
 
1,510
 
 
$
1.53
 
 
3
to
6
 
4,749
 
 
6.9
 
 
 
4.02
 
 
 
2,578
 
 
 
4.48
 
 
6
to
9
 
1,153
 
 
3.5
 
 
 
7.10
 
 
 
1,118
 
 
 
7.11
 
 
9
to
12
 
3,457
 
 
7.2
 
 
 
11.10
 
 
 
1,074
 
 
 
11.29
 
 
12
to
15
 
722
 
 
8.0
 
 
 
12.39
 
 
 
195
 
 
 
12.73
 
 
15
to
18
 
95
 
 
8.5
 
 
 
15.39
 
 
 
24
 
 
 
15.39
 
$
0
to
18
 
12,095
 
 
6.6
 
 
$
6.55
 
 
 
6,499
 
 
$
5.66
 
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]
    Non-Vested
Stock Option
Awards		   Weighted Average
Grant-Date Fair
Value
Balance December 31, 2015    
4,863
     $
6.40
  
Stock option awards granted    
2,248
      
2.17
  
Stock option awards vested    
(1,278
 )    
4.99
  
Stock option awards forfeited    
(235
 )    
6.79
  
Balance December 31, 2016    
5,598
     $
5.40