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Note 8 - Income Taxes (Tables)

12 Months Ended

Dec. 31, 2016

Notes Tables

Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]

		2016				2015				2014
Income tax benefit at federal statutory rate (35%)		$	(19,300	)		$	(15,057	)		$	(15,816	)
State and local income taxes net of federal tax benefit			(1,173	)			(819	)			(1,286	)
Permanent items			1,057				560				258
Rate change			1,080				1,012				22
Expiration of attribute carryforwards			559				330				373
Research and development tax credits			(4,681	)			(10,454	)			(748	)
Orphan drug credit			1,798				4,307				—
Other			822				(218	)			(115	)
Change in valuation allowance			19,838				20,339				17,312
Income tax expense		$	—			$	—			$	—

Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]

		2016				2015
Balance at January 1,		$	3,085			$	472
Additions to current period tax positions			1,170				2,616
Additions to prior period tax positions			—				—
Reductions to prior period tax provisions			—				(3	)
Balance at December 31,		$	4,255			$	3,085

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

		2016				2015
Deferred tax assets:
Net federal and state operating losses		$	158,618			$	142,836
Research and development credits			53,231				48,551
Fixed assets			—				1,054
Deferred revenue			3,484				4,240
Stock-based compensation			8,952				8,605
Other			2,849				2,590
Total deferred tax assets			227,134				207,876
Deferred tax liabilities:
Fixed assets			(674	)			—
Foreign currency derivative			(1,415	)			(2,668	)
Total deferred tax liabilities			(2,089	)			(2,668	)
Valuation allowance			(225,045	)			(205,208	)
Net deferred tax assets		$	—			$	—

X

- Definition

Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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+ References

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