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Note 1 - Significant Accounting Policies and Concentrations of Risk (Details Textual)
shares in Thousands, $ in Thousands
 1 Months Ended 3 Months Ended 12 Months Ended
Jun. 30, 2015
USD ($)
Mar. 31, 2016
USD ($)
Dec. 31, 2016
USD ($)
shares
Dec. 31, 2015
USD ($)
shares
Dec. 31, 2014
USD ($)
shares
Sep. 30, 2016
USD ($)
Sep. 23, 2016
USD ($)
Mar. 09, 2011
USD ($)
Long-term Line of Credit     $ 22,777        
Restricted Cash and Cash Equivalents, Current     1,546 1,612        
Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax     11 13        
Revenues     26,353 48,257 $ 13,608      
Advertising Expense       103 290      
Interest Expense     6,487 5,200 4,998      
Amortization of Debt Issuance Costs     558 439 $ 439      
Property, Plant and Equipment, Gross     14,839 19,354        
Lease Financing Obligation, Net of Current     $ 2,704 $ 2,375        
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount | shares     1,226 3,524 3,991      
Foreign Exchange Contract [Member] | Not Designated as Hedging Instrument [Member]                
Derivative, Loss on Derivative     $ 1,654 $ 564        
Derivative, Gain on Derivative     811 1,654 $ 5,487      
Birmingham Research Facility [Member]                
Interest Expense     408          
Lease Financing Obligation, Net of Current     2,704 2,375        
Capital Leases, Future Minimum Payments Due     $ 4,768          
RAPIVAB [Member] | Customer Concentration Risk [Member] | Sales Revenue, Product Line [Member]                
Number of Major Customers     3          
RAPIVAB [Member] | Customer Concentration Risk [Member] | Sales Revenue, Product Line [Member] | Three Customers [Member]                
Concentration Risk, Percentage     90.00%          
Agreement [Member] | CSL [Member] | RAPIVAB [Member]                
Proceeds from License Fees Received $ 33,740              
Revenues 21,777              
Milestone Payment Maximum 12,000              
Agreement [Member] | CSL [Member] | RAPIVAB [Member] | Revenue from Sale of Inventory to be Recognized When the Inventory Transfer Is Complete [Member]                
Deferred Revenue, Additions 3,740              
Agreement [Member] | CSL [Member] | RAPIVAB [Member] | Regulatory Support Revenue for Canadian and EU Marketing Approvals, Portion Recognized Ratably Over Expected Period of Involvement [Member]                
Deferred Revenue, Additions 1,223              
Agreement [Member] | CSL [Member] | RAPIVAB [Member] | Contingent upon EU Marketing Approval [Member]                
Proceeds from License Fees Received $ 7,000              
Computer Equipment [Member]                
Property, Plant and Equipment, Useful Life     3 years          
Laboratory Equipment, Office Equipment and Software [Member]                
Property, Plant and Equipment, Useful Life     5 years          
Furniture and Fixtures [Member]                
Property, Plant and Equipment, Useful Life     7 years          
Property, Plant and Equipment, Gross     $ 540 718        
Leasehold Improvements [Member]                
Property, Plant and Equipment, Gross     $ 8,294 5,610        
Leasehold Improvements [Member] | Birmingham Research Facility [Member]                
Property, Plant and Equipment, Useful Life     20 years 182 days          
Property, Plant and Equipment, Gross     $ 1,589 $ 1,589        
Maximum [Member]                
Maturity Period of High Quality Marketable Securities     3 years          
Average Maturity Period of High Quality Marketable Securities     1 year 180 days          
Maturity Period of Short Term Investment     1 year          
Average Maturity for Portfolio Investments     1 year 180 days          
Minimum [Member]                
Maturity Period of Short Term Investment     90 days          
Long-term Investment Maturity, Minimum     1 year          
Royalty Receivable [Member]                
Restricted Cash and Cash Equivalents, Current     $ 141          
Collateral for Credit [Member]                
Restricted Cash and Cash Equivalents, Current     $ 1,405          
Debt Issuance Costs Reclassifed from Other Current Assets [Member] | December 31, 2015 [Member]                
Prior Period Reclassification Adjustment   $ 2,196            
Senior Credit Facility [Member] | MidCap Financial Services, LLC [Member]                
Long-term Line of Credit           $ 23,000 $ 23,000  
JPR Royalty Sub LLC [Member]                
Revenue Recognition Royalty and Milestone Revenue Recognized               $ 30,000