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Note 1 - Significant Accounting Policies and Concentration of Risk - Summary of Revenues (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Product sales, net	$ 2,269	$ 6,291	$ 33
Royalty revenue	9,682	2,386	3,025
Collaborative and other research and development revenues	14,402	39,580	10,550
Revenues	26,353	48,257	13,608
US Department of Health and Human Services [Member]
Collaborative and other research and development revenues	12,449	16,337	9,366
Green Cross Corporation [Member]
Collaborative and other research and development revenues		132
Shionogi and Co. Ltd [Member]
Collaborative and other research and development revenues	1,184	1,184	1,184
Seqirus UK Limited [Member]
Collaborative and other research and development revenues	$ 769	$ 21,927

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+ References

No definition available.

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+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 225
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03.1)
-URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688

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+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 225
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03.1(e))
-URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688

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+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 225
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03.1(a))
-URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688

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