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Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Revenues
Product sales, net	$ 2,269	$ 6,291	$ 33
Royalty revenue	9,682	2,386	3,025
Collaborative and other research and development	14,402	39,580	10,550
Total revenues	26,353	48,257	13,608
Expenses
Cost of products sold	2,297	1,368	1
Research and development	61,008	72,758	51,796
Selling, general and administrative	11,253	13,047	7,461
Royalty	402	528	121
Total operating expenses	74,960	87,701	59,379
Loss from operations	(48,607)	(39,444)	(45,771)
Interest and other income	793	535	93
Interest expense	(6,487)	(5,200)	(4,998)
(Loss) gain on foreign currency derivative	(843)	1,090	5,487
Net loss	$ (55,144)	$ (43,019)	$ (45,189)
Basic and diluted net loss per common share (in dollars per share)	$ (0.75)	$ (0.59)	$ (0.68)
Weighted average shares outstanding (in shares)	73,699	72,901	66,773
Unrealized gain (loss) on available for sale investments	$ 194	$ (76)	$ (134)
Comprehensive loss	$ (54,950)	$ (43,095)	$ (45,323)

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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