Employee service share based compensation nonvested awards compensation cost expected to be recognized year four.

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Employee service share based compensation nonvested awards compensation cost expected to be recognized year three.

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Employee service share based compensation nonvested awards compensation cost expected to be recognized year two.

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Employee service share-based compensation nonvested awards compensation cost expected to be recognized next year.

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Represents percentage of common stock shares beginning.

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Represents percentage of salary to purchase common stock maximum.

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Represents share-based compensation arrangement by share-based payment award maximum value per employee amount.

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Share based compensation arrangement by share based payment award first vesting period after grant date.

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Represents the percentage of performance awards that remain unvested.

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Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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Unrecognized cost of unvested share-based compensation awards.

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Weighted average purchase price of capital shares purchased through an employee stock ownership plan.

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No definition available.

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Period which an employee's right to exercise an award is no longer contingent on satisfaction of either a service condition, market condition or a performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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The weighted average fair value at grant date for nonvested equity-based awards issued during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).

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The highest quantity of shares an employee can purchase under the plan per period.

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The maximum number of shares (or other type of equity) originally approved (usually by shareholders and board of directors), net of any subsequent amendments and adjustments, for awards under the equity-based compensation plan. As stock or unit options and equity instruments other than options are awarded to participants, the shares or units remain authorized and become reserved for issuance under outstanding awards (not necessarily vested).

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The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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Amount of accumulated difference between fair value of underlying shares on dates of exercise and exercise price on options exercised (or share units converted) into shares.

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Gross number of share options (or share units) granted during the period.

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The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

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As of the balance sheet date, the number of shares into which fully vested and expected to vest stock options outstanding can be converted under the option plan.

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As of the balance sheet date, the weighted-average exercise price for outstanding stock options that are fully vested or expected to vest.

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Percentage of vesting of share-based compensation awards.

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Amount of difference between fair value of the underlying shares reserved for issuance and exercise price of vested portions of options outstanding and currently exercisable.

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Weighted average remaining contractual term for vested portions of options outstanding and currently exercisable or convertible, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Weighted average remaining contractual term for fully vested and expected to vest options outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Fair value of options vested. Excludes equity instruments other than options, for example, but not limited to, share units, stock appreciation rights, restricted stock.

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Number of shares issued during the period as a result of an employee stock purchase plan.

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Note 7 - Share-Based Compensation (Details Textual) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended	12 Months Ended
	Aug. 31, 2013	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Allocated Share-based Compensation Expense		$ 8,487	$ 9,705	$ 10,177
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross		2,248,000
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value		$ 2.17
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized		$ 14,541
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Next Year		6,880
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Two		4,649
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Three		2,606
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Four		$ 406
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant		2,273,000	16,000	2,362,000	1,082,000
Incentive Plan [Member]
Allocated Share-based Compensation Expense		$ 8,340	$ 9,485	$ 9,963
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term		6 years 219 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value		$ 2.17	$ 7.72	$ 8.02
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value		$ 339	$ 10,117	$ 8,522
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value		20,002
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested in Period, Fair Value		$ 6,380	4,492	$ 2,844
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number		11,013
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price		$ 6.53
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term		6 years 182 days
Incentive Plan [Member] \| Employee Stock Option [Member] \| Minimum [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term		5 years
Incentive Plan [Member] \| Employee Stock Option [Member] \| Maximum [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term		10 years
Incentive Plan [Member] \| Employee Stock Option [Member] \| Non-employee Directors [Member]
Share-based Compensation Arrangement by Share-based Payment Award, First Vesting Period After Grant Date		1 year
Incentive Plan [Member] \| Employee Stock Option [Member] \| Vest 25% Each Year Until Fully Vested [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage		25.00%
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period		4 years
Incentive Plan [Member] \| Stock Options and Restricted Stock [Member] \| Vest 50% Each Year Until Fully Vested [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage		50.00%
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period		2 years
Incentive Plan [Member] \| Performance Shares [Member] \| Vest Upon Successful Completion of Specific Development Milestones [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross	1,032,000			1,250,000
Incentive Plan [Member] \| Performance Shares [Member] \| Vest Upon Successful Completion of Specific Development Milestones [Member] \| August 2013 [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage		75.00%
Share-based Compensation Arrangement by Shar-based Payment Award, Awards Unvested, Percentage		25.00%
Incentive Plan [Member] \| Performance Shares [Member] \| Vest Upon Successful Completion of Specific Development Milestones [Member] \| December 2014 [Member]
Share-based Compensation Arrangement by Shar-based Payment Award, Awards Unvested, Percentage		100.00%
Employee Stock Purchase Plan [Member]
Allocated Share-based Compensation Expense		$ 147	$ 220	$ 214
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized		1,475,000
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant		422,000
Percentage of Salary to Purchase Common Stock, Maximum		15.00%
Percentage of Common Stock Shares, Beginning		85.00%
Share-based Compensation Arrangement by Share-based Payment Award, Maximum Number of Shares Per Employee		3,000
Shar-based Compensation Arrangement by Shar-based Payment Award, Maximum Number of Shares Per Employee, Amount		$ 25
Stock Issued During Period, Shares, Employee Stock Purchase Plans		75,000	41,000	49,000
Employee Stock Ownership Plan (ESOP), Weighted Average Purchase Price of Shares Purchased		$ 4.36	$ 8.65	$ 6.29
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value		$ 1.95	$ 4.93	$ 4.41