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Note 8 - Income Taxes (Details Textual) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount	$ 19,837	$ 20,339	$ 17,312
Employee Service Share-based Compensation, Tax Benefit Realized from Exercise of Stock Options	15,655
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued	0	$ 0	$ 0
Research Tax Credit Carryforward [Member]
Tax Credit Carryforward, Amount	57,487
Domestic Tax Authority [Member]
Operating Loss Carryforwards	431,983
State and Local Jurisdiction [Member]
Operating Loss Carryforwards	$ 403,237

X

- Definition

Disclosure of the aggregate tax benefit realized from the exercise of stock options and the conversion of similar instruments during the annual period.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (j)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to increase (decrease) in the valuation allowance for deferred tax assets.

+ References

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-SubTopic 10
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Amount of operating loss carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.

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Amount accrued for interest on an underpayment of income taxes and penalties related to a tax position claimed or expected to be claimed in the tax return.

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