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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Operating activities:      
Net loss $ (55,144) $ (43,019) $ (45,189)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation, amortization, and impairment 483 180 177
Loss on disposal of property and equipment 17 27
Stock-based compensation expense 8,487 9,705 10,177
Amortization of Debt Issuance Costs 558 439 439
Amortization of premium/discount on investments 523 570 150
Change in fair value of foreign currency derivative (811) 564 (5,487)
Changes in operating assets and liabilities:      
Receivables (2,525) 3,247 (7,375)
Inventory 1,112 (929) (683)
Prepaid expenses and other assets 3,702 637 (2,093)
Deferred collaboration expense 71 (102) 59
Accounts payable and accrued expenses (10,524) 13,676 4,656
Interest payable 2,244 717 2,162
Deferred revenue (1,631) 1,199 4,429
Net cash used in operating activities: (53,438) (13,116) (38,551)
Investing activities:      
Acquisition of property and equipment (5,277) (5,122) (106)
Proceeds from sale of property and equipment 4
Change in restricted cash 66 (1,462) 1
Purchases of investments (14,106) (53,830) (73,875)
Sales and maturities of investments 42,652 42,410 34,000
Net cash provided (used) in investing activities: 23,339 (18,004) (39,980)
Financing activities:      
Sale of common stock, net 106,600
Net proceeds from common stock issued under stock-based compensation plans 317 5,479 5,307
Proceeds from senior credit facility 22,658
Increase in lease financing obligation 329
Net cash provided by financing activities: 23,304 5,479 111,907
(Decrease) increase in cash and cash equivalents (6,795) (25,641) 33,376
Cash and cash equivalents at beginning of year 28,899 54,540 21,164
Cash and cash equivalents at end of year $ 22,104 $ 28,899 $ 54,540