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Note 8 - Income Taxes - Differences Between the Company's Effective Tax Rate and the Statutory Tax Rate (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Income tax benefit at federal statutory rate (35%)	$ (19,300)	$ (15,057)	$ (15,816)
State and local income taxes net of federal tax benefit	(1,173)	(819)	(1,286)
Permanent items	1,057	560	258
Rate change	1,080	1,012	22
Expiration of attribute carryforwards	559	330	373
Research and development tax credits	(4,681)	(10,454)	(748)
Orphan drug credit	1,798	4,307
Other	822	(218)	(115)
Change in valuation allowance	19,837	20,339	17,312
Income tax expense

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