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Note 2 - Property and Equipment
12 Months Ended
Dec. 31, 2016
Notes to Financial Statements  
Property, Plant and Equipment Disclosure [Text Block]
Note 
2
 — Property and Equipment
 
Property and equipment consisted of the following at
December
 
31:
 
    2016   2015
Furniture and fixtures   $
540
    $
718
 
Office equipment    
141
     
1,122
 
Software    
1,117
     
1,427
 
Laboratory equipment    
3,252
     
6,004
 
Leased equipment    
     
63
 
Leasehold improvements    
8,294
     
5,610
 
Construction in progress    
     
2,821
 
Building    
1,495
     
1,589
 
     
14,839
     
19,354
 
Less accumulated depreciation and amortization    
(4,917
)    
(14,205
)
Property and equipment, net   $
9,922
    $
5,149
 
  
Depreciation and amortization expense for the years ended
December
 
31,
2016,
2015
and
2014
was
$483,
$180
and
$177,
respectively.